2016
Micro-RNAs and High-Density Lipoprotein Metabolism
Canfrán-Duque A, Lin CS, Goedeke L, Suárez Y, Fernández-Hernando C. Micro-RNAs and High-Density Lipoprotein Metabolism. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36: 1076-1084. PMID: 27079881, PMCID: PMC5315356, DOI: 10.1161/atvbaha.116.307028.BooksConceptsReverse cholesterol transportCardiovascular diseaseHDL metabolismCholesterol transportIschemic heart diseaseCause of deathEarlier epidemiological studiesPotential therapeutic targetBile acid synthesisMicro-RNAsCardioprotective effectsHeart diseaseEpidemiological studiesImproved preventionCholesterol effluxTherapeutic targetDensity lipoproteinCholesterol uptakeDiseaseArtery wallHDL biogenesisInverse correlationHDLLiverAcid synthesis
2009
Genetic Evidence Supporting a Critical Role of Endothelial Caveolin-1 during the Progression of Atherosclerosis
Fernández-Hernando C, Yu J, Suárez Y, Rahner C, Dávalos A, Lasunción MA, Sessa WC. Genetic Evidence Supporting a Critical Role of Endothelial Caveolin-1 during the Progression of Atherosclerosis. Cell Metabolism 2009, 10: 48-54. PMID: 19583953, PMCID: PMC2735117, DOI: 10.1016/j.cmet.2009.06.003.Peer-Reviewed Original ResearchConceptsProgression of atherosclerosisInitiation of atherosclerosisCav-1ApoE knockout backgroundArtery wallKnockout backgroundLeukocyte adhesion moleculesNitric oxide productionEndothelial Cav-1 expressionCav-1 expressionEndothelial caveolin-1AtherosclerosisTransgenic miceOxide productionGenetic ablationLDL infiltrationAdhesion moleculesCritical roleCaveolin-1 geneLDL-derived cholesterolMiceVessel wallPhysiological evidenceLesion expansionGenetic evidence