Toll-like receptor 4 deficiency causes pulmonary emphysema
Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. Toll-like receptor 4 deficiency causes pulmonary emphysema. Journal Of Clinical Investigation 2006, 116: 3050-3059. PMID: 17053835, PMCID: PMC1616193, DOI: 10.1172/jci28139.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsCells, CulturedElastinMiceMice, KnockoutMyeloid Differentiation Factor 88NADPH OxidasesOxidantsPancreatic ElastasePulmonary EmphysemaToll-Like Receptor 4ConceptsToll-like receptor 4 deficiencyEndothelial cellsOxidant generationLung structural cellsAdoptive transfer experimentsNormal lung architectureDevelopment of emphysemaTLR4 deficiencyTLR4 expressionAirspace enlargementLung diseaseLung architecturePulmonary emphysemaLung integrityCigarette smokeLung elasticityEmphysemaNADPH inhibitorStructural cellsLungNovel NADPH oxidaseNADPH oxidaseElastolytic activityTLRMice