2023
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production
Song J, Lv H, Liu B, Hao M, Taylor H, Zhang X, Li D, Huang Y. Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production. Molecular Metabolism 2023, 78: 101828. PMID: 37898449, PMCID: PMC10641683, DOI: 10.1016/j.molmet.2023.101828.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisFibrosisHepatocytesHumansLiver CirrhosisMiceMicroRNAsTransforming Growth Factor beta1ConceptsFas-mediated apoptosisLet-7Hepatocyte apoptosisNegative feedback loopMouse primary hepatocytesLet-7 miRNAsTGF-b signalingSignaling networksApoptosis of hepatocytesTransient transfectionFas expressionInhibiting hepatocyte apoptosisSiRNA knockdownLet-7 expressionLet-7 overexpressionMouse modelApoptosisPrimary hepatocytesSuppressed hepatocyte apoptosisTET3Liver fibrosisFeedback loopExpressionDriver of liver fibrosisAdeno-associated viral vectors
2022
The many faces and pathologic diagnostic challenges of autoimmune hepatitis
Zhang X, Jain D. The many faces and pathologic diagnostic challenges of autoimmune hepatitis. Human Pathology 2022, 132: 114-125. PMID: 35753409, DOI: 10.1016/j.humpath.2022.06.019.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisHistological featuresLiver diseaseAcute-onset autoimmune hepatitisDiagnosis of AIHEnd-stage liver diseaseChronic inflammatory liver diseasePathologic diagnostic challengeFatal liver failureInflammatory liver diseaseTypical histological featuresCareful clinicopathological correlationRoutine clinical practiceMajor differential diagnosisImmunosuppressive treatmentLiver histologySpecific autoantibodiesLiver failurePrompt diagnosisHistological presentationClinicopathological correlationInternational Working GroupPathological featuresDiagnostic challengeHistopathologic spectrum
2013
Histopathologic Manifestations of Drug-induced Hepatotoxicity
Zhang X, Ouyang J, Thung SN. Histopathologic Manifestations of Drug-induced Hepatotoxicity. Clinics In Liver Disease 2013, 17: 547-564. PMID: 24099017, DOI: 10.1016/j.cld.2013.07.004.Peer-Reviewed Original ResearchMeSH KeywordsAspirinCell DeathChemical and Drug Induced Liver InjuryHepatocytesHumansImmunohistochemistryConceptsDrug-induced hepatotoxicityChronic liver diseaseLiver diseaseCareful medication historySpecific histopathologic patternAbnormal liver testsLiver testsResponsible drugSymptom onsetLiver injuryMedication historyCounter medicationsHistopathologic patternHistopathologic findingsDrug exposureHistopathologic manifestationsHepatobiliary diseaseCertain drugsSupplementary agentPrescription drugsHepatotoxicityHerbal productsLatent periodDiseaseDrugs