Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis
González IA, Fuller LD, Zhang X, Papke DJ, Zhao L, Zhang D, Liao X, Liu X, Fiel MI, Zhang X. Development of a Scoring System to Differentiate Amiodarone-Induced Liver Injury From Alcoholic Steatohepatitis. American Journal Of Clinical Pathology 2021, 157: 434-442. PMID: 34596220, DOI: 10.1093/ajcp/aqab142.Peer-Reviewed Original ResearchConceptsAmiodarone-induced liver injuryAlcoholic steatohepatitisScoring systemLiver injuryTest cohortDifferent histologic featuresHepatocyte ballooning degenerationMallory-Denk bodiesNeutrophilic inflammationHistologic featuresPericellular fibrosisMacrovesicular steatosisBallooning degenerationHistologic differencesLiver parenchymaCohortSteatohepatitisInjuryFurther validationInitial studyZone 1SatellitosisCholestasisSteatosisInflammationα-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHepatocytic lesionsDiagnosis of HCCLiver biopsy cohortHepatocyte paraffin 1Independent retrospective cohortsBenign liver lesionsMulti-center studyGood diagnostic valueNovel diagnostic biomarkersArginase-1 (Arg-1) proteinsΑ-fetoprotein mRNASurgical cohortRetrospective cohortBiopsy cohortHepPar-1Arg-1Liver lesionsDiagnostic biomarkersDiagnostic valueMalignancy lesionsLesionsGlypican3CohortSpecific markers