SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells
Ouyang X, Fujimoto M, Nakagawa R, Serada S, Tanaka T, Nomura S, Kawase I, Kishimoto T, Naka T. SOCS‐2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells. Journal Of Cellular Physiology 2006, 207: 428-436. PMID: 16419040, DOI: 10.1002/jcp.20579.Peer-Reviewed Original ResearchMeSH KeywordsAlkaline PhosphataseAnimalsBone Morphogenetic Protein 6Bone Morphogenetic ProteinsCell DifferentiationCell LineCell SurvivalChlorocebus aethiopsCOS CellsGene ExpressionLeupeptinsMiceMuscle Fibers, SkeletalMyoblastsMyoD ProteinMyogeninOsteoblastsOsteocalcinPhosphorylationProtein Kinase InhibitorsProto-Oncogene Proteins c-junSmad ProteinsSuppressor of Cytokine Signaling ProteinsTransfectionUp-RegulationConceptsC2C12 cellsJunB protein expressionSOCS-2Mesenchymal precursorsMyotube formationSmad-responsive reporter geneUbiquitin-proteasome pathwayCOS-7 cellsProtein expressionKey transcriptional factorBMP/SmadPrecursor cell lineSuppressor of cytokineGrowth hormone signalingSOCS familyCell fateHormone signalingTranscriptional activationBone morphogenic proteinAcceleration of proliferationTranscriptional levelReporter geneTranscriptional factorsNuclear accumulationJunB protein