2002
Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells
Takahashi K, Ouyang X, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochemical Pharmacology 2002, 64: 745-750. PMID: 12167494, DOI: 10.1016/s0006-2952(02)01250-9.Peer-Reviewed Original ResearchConceptsSodium tanshinone IIA sulfonateAngiotensin IITanshinone IIA sulfonateEffect of STSCultured neonatal rat cardiac cellsCardiac cellsCultured cardiac cellsS. miltiorrhiza extractImmediate early gene expressionNeonatal rat heartsAttenuates hypertrophyCardiovascular diseaseC-jun expressionRat cardiac cellsDiphenylformazan assayRat heartTherapeutic basisCardiac fibroblastsNeonatal rat cardiac cellsEarly gene expressionCultured myocytesHypertrophyTanshinone IIAExact mechanismMyocytes
2001
Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells
Ouyang X, Takahashi K, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells. Journal Of Pharmacological Sciences 2001, 87: 289-296. PMID: 11829148, DOI: 10.1254/jjp.87.289.Peer-Reviewed Original ResearchConceptsCultured neonatal rat cardiac cellsAng IIRat cardiac cellsNeonatal rat cardiac cellsCardiac cellsHypertrophic responseSalvia miltiorrhizaImmediate early response gene expressionAng II actionAng II stimulationChronotropic responsivenessAngiotensin IIMorphological injuryDose-dependent cytotoxicityII stimulationProtective effectEarly response gene expressionDifferent pharmacological activitiesEthyl acetate insoluble fractionResponse gene expressionTanshinone IIAHypertrophic growthPharmacological activitiesCardiomyocytesEffective constituents