Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells
Takahashi K, Ouyang X, Komatsu K, Nakamura N, Hattori M, Baba A, Azuma J. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochemical Pharmacology 2002, 64: 745-750. PMID: 12167494, DOI: 10.1016/s0006-2952(02)01250-9.Peer-Reviewed Original ResearchConceptsSodium tanshinone IIA sulfonateAngiotensin IITanshinone IIA sulfonateEffect of STSCultured neonatal rat cardiac cellsCardiac cellsCultured cardiac cellsS. miltiorrhiza extractImmediate early gene expressionNeonatal rat heartsAttenuates hypertrophyCardiovascular diseaseC-jun expressionRat cardiac cellsDiphenylformazan assayRat heartTherapeutic basisCardiac fibroblastsNeonatal rat cardiac cellsEarly gene expressionCultured myocytesHypertrophyTanshinone IIAExact mechanismMyocytes