2022
Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C]glucose infusion and 1H-[13C]NMR ex vivo
McNair LM, Mason GF, Chowdhury GM, Jiang L, Ma X, Rothman DL, Waagepetersen HS, Behar KL. Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2-13C]/[1-13C]glucose infusion and 1H-[13C]NMR ex vivo. Cerebrovascular And Brain Metabolism Reviews 2022, 42: 1507-1523. PMID: 35048735, PMCID: PMC9274856, DOI: 10.1177/0271678x221074211.Peer-Reviewed Original ResearchConceptsCerebral cortexThree-compartment metabolic modelBrain regionsAwake male ratsTime courseMultiple brain regionsAwake ratsMale ratsAwake humansNeurotransmitter cyclingBrain rateAnesthetized rodentsEx vivoRate of glutamateCortexHippocampusStriatumGlutamateRatsBlood plasmaCerebellumGlucose consumptionGlucose oxidationRapid euthanasiaCortical data
2016
Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects
Chowdhury GM, Zhang J, Thomas M, Banasr M, Ma X, Pittman B, Bristow L, Schaeffer E, Duman RS, Rothman DL, Behar KL, Sanacora G. Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects. Molecular Psychiatry 2016, 22: 120-126. PMID: 27067013, PMCID: PMC5345902, DOI: 10.1038/mp.2016.34.Peer-Reviewed Original ResearchConceptsAntidepressant-like efficacyAntidepressant actionRo 25Glutamate cyclingAntidepressant-like effectsRapid antidepressant effectsClear dose-dependent effectRapid antidepressant actionsDose-dependent effectEffects of scopolamineRapid transient riseAntidepressant effectsAntidepressant propertiesIntravenous infusionSingle doseAntidepressant activityIntraperitoneal injectionClinical trialsDrug injectionAwake ratsNovel agentsRat PFCRodent modelsRapid onsetUnique drug