Featured Publications
Orbital and Periorbital Dysmorphology in Untreated Pfeiffer Syndrome
Lu X, Forte AJ, Allam O, Park KE, Wilson A, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Orbital and Periorbital Dysmorphology in Untreated Pfeiffer Syndrome. Plastic & Reconstructive Surgery 2022, 149: 731e-742e. PMID: 35171849, DOI: 10.1097/prs.0000000000008928.Peer-Reviewed Original ResearchConceptsPfeiffer syndrome patientsMonths of ageOrbital cavity volumeSyndrome patientsPfeiffer patientsSphenoid boneGlobe volumeAnterior positioningCLINICAL QUESTION/LEVELNormal control subjectsYears of ageSoft tissue volumeControl subjectsSignificant hypoplasiaPatientsBone volumePfeiffer syndromeVisual impairmentBony orbitAnteroposterior lengthMaxillaVolumetric analysisAgeMonthsMaterialise softwareAirway Growth in Preoperative Patients with Crouzon Syndrome
Lu X, Forte AJ, Park KE, Allam O, Smetona J, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Airway Growth in Preoperative Patients with Crouzon Syndrome. Facial Plastic Surgery & Aesthetic Medicine 2021, 23: 191-197. PMID: 33577380, DOI: 10.1089/fpsam.2020.0441.Peer-Reviewed Original ResearchConceptsYears of ageNasal airway volumeAirway volumeCrouzon syndromePharyngeal airwayCross-sectional areaAirway cross-sectional areaObstructive sleep apneaMonths of agePreoperative patientsSleep apneaMaximal constrictionAirway developmentAirway growthTomography scanAge subgroupsCT scanPatientsSyndromeCrouzon patientsNatural historyAgeNormal dimensionsAirwayMaterialise softwareMorphological Basis for Airway Surgical Intervention in Apert Syndrome
Lu X, Forte AJ, Park KE, Allam O, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Morphological Basis for Airway Surgical Intervention in Apert Syndrome. Annals Of Plastic Surgery 2020, 87: 59-64. PMID: 34133365, DOI: 10.1097/sap.0000000000002601.Peer-Reviewed Original ResearchConceptsApert syndrome patientsPharyngeal airway volumeComputed tomography scanSyndrome patientsApert syndromeAirway volumeSurgical interventionTomography scanNasal cavityPreoperative computed tomography scansAirway volume changesAge-related subgroupsYears of ageMonths of agePosition of maxillaGrowth of mandibleAirway compromiseNasopharyngeal airwayPharyngeal airwayNasal airwayIntergonial widthSyndromeAirwayPatientsAnteroposterior lengthSphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis.
Lu X, Forte AJ, Park KE, Allam O, Mozaffari MA, Alperovich M, Steinbacher DM, Alonso N, Persing JA. Sphenoid Bone Structure and Its Influence on the Cranium in Syndromic Versus Nonsyndromic Craniosynostosis. Journal Of Craniofacial Surgery 2020, 32: 67-72. PMID: 32868725, DOI: 10.1097/scs.0000000000006914.Peer-Reviewed Original Research
2020
Cranial Fossa Volume and Morphology Development in Apert Syndrome.
Lu X, Forte AJ, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Cranial Fossa Volume and Morphology Development in Apert Syndrome. Plastic & Reconstructive Surgery 2020, 145: 790e-802e. PMID: 32221226, DOI: 10.1097/prs.0000000000006679.Peer-Reviewed Original Research
2019
Enlarged anterior cranial fossa and restricted posterior cranial fossa, the disproportionate growth of basicranium in Crouzon syndrome
Lu X, Forte AJ, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Enlarged anterior cranial fossa and restricted posterior cranial fossa, the disproportionate growth of basicranium in Crouzon syndrome. Journal Of Cranio-Maxillofacial Surgery 2019, 47: 1426-1435. PMID: 31331854, DOI: 10.1016/j.jcms.2019.06.003.Peer-Reviewed Original ResearchConceptsPosterior cranial fossa volumePosterior cranial fossaCranial fossaFossa volumeCrouzon syndrome patientsCrouzon syndromeSyndrome patientsCT scanSegmental anteriorSurgical treatment planPreoperative CT scanAnterior cranial fossaMonths of ageMiddle cranial fossaPosterior cranial expansionNormal intracranial volumeIntracranial volume measurementsTreatment planIntracranial volumePatientsFossaSyndromeCranial expansionCranial volumeAnteriorTemporal Evaluation of Craniofacial Relationships in Apert Syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Gabrick K, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Temporal Evaluation of Craniofacial Relationships in Apert Syndrome. Journal Of Craniofacial Surgery 2019, 30: 317-325. PMID: 30358751, DOI: 10.1097/scs.0000000000004836.Peer-Reviewed Original ResearchConceptsYears of ageApert syndromeNasal spineComputed tomography scanMaxillary planeAnterior nasal spineMonths of ageApert syndrome patientsPosterior nasal spineSella-nasion planeTomography scanSyndrome patientsAge subgroupsAnatomic relationshipsSyndromeFacial deformityAngulation changeFrankfort horizontal planeCranial base lengthMonthsIntracellular regulatory mechanismsCraniofacial malformationsAgeDeformityMaterialize software
2018
Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome. International Journal Of Oral And Maxillofacial Surgery 2018, 48: 309-321. PMID: 30389113, DOI: 10.1016/j.ijom.2018.10.013.Peer-Reviewed Original ResearchConceptsCrouzon syndromeCT scanAnteroposterior lengthWidth of maxillaPreoperative CT scanMonths-2 yearsMonths of agePrincipal deformityControl subjectsGlobe projectionAge subgroupsMaxillary wideningSecondary deformitiesOrbital wallAnterior protrusionSyndromeFacial malformationsMonthsDeformityAnteroposterior positionZygomatic regionCranial baseZygomaMalformationsMaterialise softwareFacial Malformation in Crouzon’s Syndrome Is Consistent with Cranial Base Development in Time and Space
Lu X, Forte AJ, Sawh-Martinez R, Madari S, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Facial Malformation in Crouzon’s Syndrome Is Consistent with Cranial Base Development in Time and Space. Plastic & Reconstructive Surgery Global Open 2018, 6: e1963. PMID: 30534503, PMCID: PMC6250456, DOI: 10.1097/gox.0000000000001963.Peer-Reviewed Original ResearchCranial base deformitySyndrome patientsCrouzon syndromeFrankfort horizontal planeSurgical decision makingAnterior cranial fossaCranial baseMonths of ageCranial base developmentEvident morphologic changesCrouzon syndrome patientsAnterior cranial baseSella-nasion planeTomography scanCranial fossaCrouzon patientsSyndromeMorphologic changesPatientsMandibular planeFacial malformationsPosterior cranial baseDeformityMaxillary planeSella-NasionNormal angulation of skull base in Apert syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Normal angulation of skull base in Apert syndrome. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 2042-2051. PMID: 30391086, DOI: 10.1016/j.jcms.2018.09.026.Peer-Reviewed Original ResearchConceptsAnterior cranial baseApert syndromeCranial base lengthSkull baseSevere craniofacial deformitiesPosterior cranial base lengthYears of ageMonths of ageUnoperated patientsCT scanAnterior cranial base lengthCranial base angleLate infancySyndromeAge rangeCraniofacial deformitiesCranial baseDeformityAdditive effectSkull vaultMonthsAngulationSignificant changesAgeBase length