2021
Multivariate log‐contrast regression with sub‐compositional predictors: Testing the association between preterm infants' gut microbiome and neurobehavioral outcomes
Liu X, Cong X, Li G, Maas K, Chen K. Multivariate log‐contrast regression with sub‐compositional predictors: Testing the association between preterm infants' gut microbiome and neurobehavioral outcomes. Statistics In Medicine 2021, 41: 580-594. PMID: 34897772, DOI: 10.1002/sim.9273.Peer-Reviewed Original ResearchConceptsLinear log-contrast modelLog-contrast modelGut microbiomeGut microbiome of preterm infantsHypothesis testing procedureInfant gut microbiomeLinear constraintsCompositional covariatesInference proceduresMultivariate responsePenalization approachSimulation studyGroup structureMicrobiome dataIdentified microbesMicrobiome analysisTaxonomic hierarchyInference methodsPreterm infant studyTest procedureMicrobiomeMicrobesBiological understandingCovariatesFeature matrix
2018
Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection
Xu W, Luo Z, Alekseyenko A, Martin L, Wan Z, Ling B, Qin Z, Heath S, Maas K, Cong X, Jiang W. Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Scientific Reports 2018, 8: 12863. PMID: 30150778, PMCID: PMC6110826, DOI: 10.1038/s41598-018-31116-y.Peer-Reviewed Original ResearchConceptsAnti-CD4 IgGVirally suppressive antiretroviral therapyAnti-CD4 autoantibodiesHIV+ subjectsMicrobial translocationAntiretroviral therapyAutoantibody productionPlasma levelsCD4+ T-cell recoveryChronically HIV-1-infected patientsPlasma anti-CD4 IgG levelsHealthy controlsPlasma levels of autoantibodiesHIV-1-infected patientsAssociated with plasma levelsElevated microbial translocationSystemic microbial translocationHIV-infected subjectsT-cell recoveryReduced microbial diversityLevels of autoantibodiesLimulus amebocyte assayHIV infectionPlasma microbiomeHIV disease
2017
Influence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants
Cong X, Judge M, Xu W, Diallo A, Janton S, Brownell E, Maas K, Graf J. Influence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants. Nursing Research 2017, 66: 123-133. PMID: 28252573, PMCID: PMC5334772, DOI: 10.1097/nnr.0000000000000208.Peer-Reviewed Original ResearchConceptsGut microbial colonizationMother's own milkPreterm infantsGut microbiomeMicrobial diversityDiversity of gut microbiomeFeeding typeGut microbial diversityGut microbiome developmentGut microbiome compositionMicrobial community patternsAbundance of EnterobacterialesIncreased microbial diversityDevelopment of preterm infantsAbundance of ClostridialesNeonatal intensive care unitBirth gestational ageStable preterm infantsRRNA genePostnatal day 0Community patternsMicrobiome compositionIntensive care unitMicrobial patternsMicrobiome development
2016
Gut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender
Cong X, Xu W, Janton S, Henderson W, Matson A, McGrath J, Maas K, Graf J. Gut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender. PLOS ONE 2016, 11: e0152751. PMID: 27111847, PMCID: PMC4844123, DOI: 10.1371/journal.pone.0152751.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansInfant FoodInfant, NewbornInfant, PrematureIntestinesMaleMicrobiotaSex FactorsConceptsOperational taxonomic unitsGut microbiomeA-diversityGut microbiotaNeonatal intensive care unitPreterm infantsPatterns of gut microbiomeDiversity of gut microbiomeRRNA gene regionInfant gut microbiomeFeeding typeAbundance of EnterobacterialesGut microbiome patternsTaxonomic unitsAbundant phylumGene regionTotal readsAlpha diversityQIIME softwareV4 regionBacterial compositionDevelopmental patternsEarly lifeInfant's postnatal ageMicrobiome patterns