Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection
Xu W, Luo Z, Alekseyenko A, Martin L, Wan Z, Ling B, Qin Z, Heath S, Maas K, Cong X, Jiang W. Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection. Scientific Reports 2018, 8: 12863. PMID: 30150778, PMCID: PMC6110826, DOI: 10.1038/s41598-018-31116-y.Peer-Reviewed Original ResearchConceptsAnti-CD4 IgGVirally suppressive antiretroviral therapyAnti-CD4 autoantibodiesHIV+ subjectsMicrobial translocationAntiretroviral therapyAutoantibody productionPlasma levelsCD4+ T-cell recoveryChronically HIV-1-infected patientsPlasma anti-CD4 IgG levelsHealthy controlsPlasma levels of autoantibodiesHIV-1-infected patientsAssociated with plasma levelsElevated microbial translocationSystemic microbial translocationHIV-infected subjectsT-cell recoveryReduced microbial diversityLevels of autoantibodiesLimulus amebocyte assayHIV infectionPlasma microbiomeHIV disease