Oral Enrichment of Streptococcus and its Role in Systemic Inflammation Related to Monocyte Activation in Humans with Cocaine Use Disorder
Fu X, Cheng D, Luo Z, Wagner A, Fitting S, Cong X, Xu W, Maas K, Wan Z, Zhu J, Zhou Z, Stoops W, McRae-Clark A, Jiang W. Oral Enrichment of Streptococcus and its Role in Systemic Inflammation Related to Monocyte Activation in Humans with Cocaine Use Disorder. Journal Of Neuroimmune Pharmacology 2021, 17: 305-317. PMID: 34448131, PMCID: PMC8881519, DOI: 10.1007/s11481-021-10007-6.Peer-Reviewed Original ResearchConceptsCocaine use disorderMacrophage-derived chemokineCocaine usersSystemic inflammationMonocyte chemoattractant protein (MCP)-4Use disorderExposure to cocaineMonocyte activation markersMyeloid cell activationActivation-regulated chemokineChronic systemic inflammationIncreased plasma levelsPrimary human monocytesNon-usersMIP-3aActivation markersCocaine useSaliva levelsMonocyte activationPlasma levelsProinflammatory cytokinesOral microbiomeOral streptococciCocaineCell activation