2022
Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested case-control studySymptomsCase-control studySerotonin
2021
Behavioral and neuroanatomical outcomes following altered serotonin expression in a hypoxic-ischemic injury neonate rodent model.
Casavant S, Li H, Cong X, Starkweather A, Moore J, Rosenkrantz T, Fitch R. Behavioral and neuroanatomical outcomes following altered serotonin expression in a hypoxic-ischemic injury neonate rodent model. Journal Of Neonatal-Perinatal Medicine 2021, 14: 353-360. PMID: 33164949, DOI: 10.3233/npm-200418.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitNeonatal rodent modelHypoxic-ischemicSLC6A4 methylationRodent modelsNeuroanatomical outcomesSSRI-treated subjectsWistar rat pupsSerotonin transporter proteinIntensive care unitIncreased incidence of autism spectrum disorderChronic SSRIBehavioral tasksHI injuryHemorrhagic eventsRat pupsIncidence of autism spectrum disordersSerotonin expressionSerotonin levelsPresence of injuryAssociated with methylationSSRIsTreated subjectsSham groupIncreased incidence