Behavioral and neuroanatomical outcomes following altered serotonin expression in a hypoxic-ischemic injury neonate rodent model.
Casavant S, Li H, Cong X, Starkweather A, Moore J, Rosenkrantz T, Fitch R. Behavioral and neuroanatomical outcomes following altered serotonin expression in a hypoxic-ischemic injury neonate rodent model. Journal Of Neonatal-Perinatal Medicine 2021, 14: 353-360. PMID: 33164949, DOI: 10.3233/npm-200418.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitNeonatal rodent modelHypoxic-ischemicSLC6A4 methylationRodent modelsNeuroanatomical outcomesSSRI-treated subjectsWistar rat pupsSerotonin transporter proteinIntensive care unitIncreased incidence of autism spectrum disorderChronic SSRIBehavioral tasksHI injuryHemorrhagic eventsRat pupsIncidence of autism spectrum disordersSerotonin expressionSerotonin levelsPresence of injuryAssociated with methylationSSRIsTreated subjectsSham groupIncreased incidence