Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review
Casavant S, Cong X, Moore J, Starkweather A. Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review. Early Human Development 2019, 131: 63-74. PMID: 30870624, DOI: 10.1016/j.earlhumdev.2019.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAngiomotinsBrain-Derived Neurotrophic FactorEpigenesis, GeneticHumansInfant, NewbornInfant, PrematureInsulin-Like Growth Factor IIIntensive Care Units, NeonatalIntercellular Signaling Peptides and ProteinsMembrane ProteinsMicrofilament ProteinsNeurodevelopmental DisordersNF-KappaB Inhibitor alphaReceptors, GlucocorticoidStress, PhysiologicalTacrolimus Binding ProteinsTelomereConceptsNeonatal intensive care unitPreterm infantsEpigenetic alterationsAssociated with increased riskLong-term outcome measuresTelomere erosionIntensive care unitBorn pretermTelomere lengthPreterm birthNeurodevelopmental outcomesPretermDisease entityPainful proceduresCare unitPreferred Reporting ItemsInfant stressHuman studiesLife-saving careTherapeutic interventionsOutcome measuresPsychiatric diseasesEarly detectionSystematic reviewReporting ItemsAllostatic Load and Biomarkers of Stress in the Preterm Infant: An Integrative Review
Casavant S, Cong X, Fitch R, Moore J, Rosenkrantz T, Starkweather A. Allostatic Load and Biomarkers of Stress in the Preterm Infant: An Integrative Review. Biological Research For Nursing 2019, 21: 210-223. PMID: 30654634, DOI: 10.1177/1099800418824415.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitPreterm infantsLong-term outcome measuresMarkers of oxidative stressIntensive care unitBorn pretermNociceptive inputNonnoxious stimuliBrain-gut-microbiome axisPretermPainful proceduresCare unitHuman studiesInclusion criteriaLife-saving careTherapeutic interventionsInfantsOutcome measuresEarly detectionTime pointsBiomarkersActivation of stress responsesCortisol levelsOxidative stressSystematic search