Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain
Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf B, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett E, Jiang W. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain. EBioMedicine 2021, 74: 103701. PMID: 34826801, PMCID: PMC8626580, DOI: 10.1016/j.ebiom.2021.103701.Peer-Reviewed Original ResearchConceptsCannabis smokersActinomyces meyeriCannabis smokingCentral nervous systemOral pathobiontsChronic cannabis smokersMacrophage infiltrationCannabis use disorderOral microbiomeOral microbial dysbiosisSaliva microbiomeNon-smoking controlsIncreased macrophage infiltrationCannabis exposureUse disorderMicrobial 16S rRNA sequencingCannabisCNS abnormalitiesProtein productionActinomyces odontolyticusOral bacteriaBehavioral changesNon-smokersMicrobial dysbiosisNervous systemOral Enrichment of Streptococcus and its Role in Systemic Inflammation Related to Monocyte Activation in Humans with Cocaine Use Disorder
Fu X, Cheng D, Luo Z, Wagner A, Fitting S, Cong X, Xu W, Maas K, Wan Z, Zhu J, Zhou Z, Stoops W, McRae-Clark A, Jiang W. Oral Enrichment of Streptococcus and its Role in Systemic Inflammation Related to Monocyte Activation in Humans with Cocaine Use Disorder. Journal Of Neuroimmune Pharmacology 2021, 17: 305-317. PMID: 34448131, PMCID: PMC8881519, DOI: 10.1007/s11481-021-10007-6.Peer-Reviewed Original ResearchConceptsCocaine use disorderMacrophage-derived chemokineCocaine usersSystemic inflammationMonocyte chemoattractant protein (MCP)-4Use disorderExposure to cocaineMonocyte activation markersMyeloid cell activationActivation-regulated chemokineChronic systemic inflammationIncreased plasma levelsPrimary human monocytesNon-usersMIP-3aActivation markersCocaine useSaliva levelsMonocyte activationPlasma levelsProinflammatory cytokinesOral microbiomeOral streptococciCocaineCell activation