2023
The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study
Chen J, Li H, Zhao T, Chen K, Chen M, Sun Z, Xu W, Maas K, Lester B, Cong X. The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study. Microorganisms 2023, 11: 814. PMID: 36985387, PMCID: PMC10056840, DOI: 10.3390/microorganisms11030814.Peer-Reviewed Original ResearchNeonatal intensive care unitNeonatal neurobehavioral scaleNeonatal intensive care unit hospitalizationOperational taxonomic unitsPreterm infantsPost-menstrual ageNeurobehavioral developmentGut microbiotaNeonatal intensive care unit admissionWeeks of post-menstrual ageFifty-five infantsDaily stool samplesIntensive care unitLongitudinal cohort studyImpact of early life experiencesNeurobehavioral ScalePretermPostnatal dayClinical featuresCohort studyEarly life experiencesStool samplesCare unitNeurobehavioral outcomesInfants
2021
Sex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis
Chen J, Li H, Hird S, Chen M, Xu W, Maas K, Cong X. Sex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis. Frontiers In Cellular And Infection Microbiology 2021, 11: 671074. PMID: 34458157, PMCID: PMC8387566, DOI: 10.3389/fcimb.2021.671074.Peer-Reviewed Original ResearchConceptsStatistical Analysis of Metagenomic ProfilesNeonatal intensive care unitGut microbiotaGut microbiomeFunction of gut microbiotaCharacteristics of gut microbiotaReconstruction of Unobserved StatesPhylogenetic Investigation of CommunitiesGut microbial developmentGut microbiota patternInfant gut microbiotaGut microbiota compositionGut microbiome diversityInvestigation of CommunitiesInfant gut microbiomePostnatal ageNeurobehavioral developmentMetagenomic functionsMixed-sex groupsPhylogenetic investigationMetagenomic profilesEnvironmental factorsMicrobiota compositionKEGG pathwaysMicrobiome diversity
2017
The impact of cumulative pain/stress on neurobehavioral development of preterm infants in the NICU
Cong X, Wu J, Vittner D, Xu W, Hussain N, Galvin S, Fitzsimons M, McGrath J, Henderson W. The impact of cumulative pain/stress on neurobehavioral development of preterm infants in the NICU. Early Human Development 2017, 108: 9-16. PMID: 28343092, PMCID: PMC5444300, DOI: 10.1016/j.earlhumdev.2017.03.003.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitPreterm infantsNeurobehavioral outcomesNeurobehavioral development of preterm infantsOutcomes of preterm infantsDevelopment of preterm infantsSkin-to-skin holdingVulnerable preterm infantsIntensive care unitProspective exploratory studyInfant developmental outcomesNeurodevelopmental outcomesAltered neurodevelopmentNeurobehavioral developmentCare unitNeuroprotective strategiesInfantsAssociated with habituationAcute eventPretermEarly lifeOutcomesNeurodevelopmentDevelopmental outcomesCumulative timeFKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants
D'Agata A, Walsh S, Vittner D, Cong X, McGrath J, Young E. FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants. Developmental Psychobiology 2017, 59: 410-418. PMID: 28247564, DOI: 10.1002/dev.21507.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitNeurobehavioral outcomesNeonatal intensive care unit stressNeonatal intensive care unit careFKBP5 genotypeIntensive care unitEarly life stress exposureStress response-associated genesGenetic susceptibility to stressInfant neurobehavioral developmentPreterm infantsImpact of genetic variationNeurodevelopmental impairmentResponse-associated genesLife stress exposureNeurobehavioral developmentCare unitEnvironmental risk factorsRisk factorsInfant problemsAssociated with neurobehavioral outcomesStatistical analysisPretermSusceptibility to stressStress exposure
2012
Maternal consumption of a DHA-containing functional food benefits infant sleep patterning: An early neurodevelopmental measure
Judge M, Cong X, Harel O, Courville A, Lammi-Keefe C. Maternal consumption of a DHA-containing functional food benefits infant sleep patterning: An early neurodevelopmental measure. Early Human Development 2012, 88: 531-537. PMID: 22269042, DOI: 10.1016/j.earlhumdev.2011.12.016.Peer-Reviewed Original ResearchConceptsInfant sleep patternsPlacebo groupSleep organizationInfant sleep/wake stateMaternal DHA intakeFetal neural tissuePlacebo-controlled designPostnatal day 1Early neurobehavioral developmentSleep patternsPlacebo barWeeks gestationPostnatal hoursDouble-blindPregnancy complicationsQuiet sleepActive sleepMaternal consumptionDHA intakeSleep/wake statesDay 1Neurobehavioral developmentPrenatal supplyPregnancyOrganism sleep