2022
Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization
Chen J, Li H, Maas K, Starkweather A, Chen M, Cong X. Sex-specific gut microbiome profiles among preterm infants during the neonatal intensive care hospitalization. Interdisciplinary Nursing Research 2022, 1: 6-13. PMID: 36590867, PMCID: PMC9766955, DOI: 10.1097/nr9.0000000000000004.Peer-Reviewed Original ResearchGut microbiome profilesNeonatal intensive care unitNeonatal intensive care unit hospitalizationMicrobiome profilesGut microbiotaPreterm infantsStool samplesComposition of gut microbiotaPredicted metabolic functionsPredictive functional profilingNeonatal gut microbiotaBacterial taxonomic compositionGut microbiota compositionAbundance of membranePreterm neonatesGlycan biosynthesisLipopolysaccharide biosynthesisNeonatal intensive care hospitalizationTaxonomic compositionGene regionB-diversityGut microbiomeMicrobiota compositionMale preterm neonatesDiversity indexAssociations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested case-control studySymptomsCase-control studySerotonin
2021
Multivariate log‐contrast regression with sub‐compositional predictors: Testing the association between preterm infants' gut microbiome and neurobehavioral outcomes
Liu X, Cong X, Li G, Maas K, Chen K. Multivariate log‐contrast regression with sub‐compositional predictors: Testing the association between preterm infants' gut microbiome and neurobehavioral outcomes. Statistics In Medicine 2021, 41: 580-594. PMID: 34897772, DOI: 10.1002/sim.9273.Peer-Reviewed Original ResearchConceptsLinear log-contrast modelLog-contrast modelGut microbiomeGut microbiome of preterm infantsHypothesis testing procedureInfant gut microbiomeLinear constraintsCompositional covariatesInference proceduresMultivariate responsePenalization approachSimulation studyGroup structureMicrobiome dataIdentified microbesMicrobiome analysisTaxonomic hierarchyInference methodsPreterm infant studyTest procedureMicrobiomeMicrobesBiological understandingCovariatesFeature matrixSex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis
Chen J, Li H, Hird S, Chen M, Xu W, Maas K, Cong X. Sex Differences in Gut Microbial Development of Preterm Infant Twins in Early Life: A Longitudinal Analysis. Frontiers In Cellular And Infection Microbiology 2021, 11: 671074. PMID: 34458157, PMCID: PMC8387566, DOI: 10.3389/fcimb.2021.671074.Peer-Reviewed Original ResearchConceptsStatistical Analysis of Metagenomic ProfilesNeonatal intensive care unitGut microbiotaGut microbiomeFunction of gut microbiotaCharacteristics of gut microbiotaReconstruction of Unobserved StatesPhylogenetic Investigation of CommunitiesGut microbial developmentGut microbiota patternInfant gut microbiotaGut microbiota compositionGut microbiome diversityInvestigation of CommunitiesInfant gut microbiomePostnatal ageNeurobehavioral developmentMetagenomic functionsMixed-sex groupsPhylogenetic investigationMetagenomic profilesEnvironmental factorsMicrobiota compositionKEGG pathwaysMicrobiome diversityMulti-Omics Analysis on Neurodevelopment in Preterm Neonates
Casavant S, Chen J, Xu W, Lainwala S, Matson A, Chen M, Starkweather A, Maas K, Cong X. Multi-Omics Analysis on Neurodevelopment in Preterm Neonates. Nursing Research 2021, 70: 462-468. PMID: 34380978, PMCID: PMC8563389, DOI: 10.1097/nnr.0000000000000548.Peer-Reviewed Original ResearchConceptsPreterm infantsIntensive care unitNecrotizing enterocolitisFeeding intoleranceNeurodevelopmental impairmentNeonatal intensive care unit periodAdverse outcomesHost genetic variationIntestinal microbiomePreterm infants born <Care unitNeonatal intensive care unitInfants born <Weeks gestational ageGut microbiomeIntensive care unit periodFollow-up visitRegulation of intestinal healthPreterm neonatesGestational agePotential adverse outcomesNeurodevelopmental outcomesPain sensitivityPretermMulti-omics analysisAn Integrative Review of the Role of the Oral and Gut Microbiome in Oral Health Symptomatology During Cancer Therapy.
Dunnack H, Judge M, Cong X, Salner A, Duffy V, Xu W. An Integrative Review of the Role of the Oral and Gut Microbiome in Oral Health Symptomatology During Cancer Therapy. Oncology Nursing Forum 2021, 48: 317-331. PMID: 33855998, DOI: 10.1188/21.onf.317-331.Peer-Reviewed Original ResearchConceptsRadiation therapyCancer therapyManagement of oral mucositisHead and neck cancerReducing mucositis severityPatient's oral healthOral health symptomsOral health managementGut microbiomeAssociated with increased severityHealth symptomatologyMucositis severityOral mucositisOral healthMicrobial interventionsNeck cancerSolid tumorsStudy assessed symptomsTherapyChemotherapyNutritional statusCancer treatmentQuality of lifeBlood cancerCancer
2020
Altered Composition of Gut Microbiota in Depression: A Systematic Review
Barandouzi Z, Starkweather A, Henderson W, Gyamfi A, Cong X. Altered Composition of Gut Microbiota in Depression: A Systematic Review. Frontiers In Psychiatry 2020, 11: 541. PMID: 32587537, PMCID: PMC7299157, DOI: 10.3389/fpsyt.2020.00541.Peer-Reviewed Original ResearchGut microbiota patternMicrobiota patternsComposition of gut microbiotaLow abundanceClostridium IV</i>Clostridium XlVa</i>Gut microbiome patternsBrain-gut-microbiome axisGenus levelGut microbiotaB-diversityGut microbiomePhylum levelA-diversityMicrobiome patternsGastrointestinal microbiomeFamily levelMicrobiome findingsMicrobiotaAltered compositionAbundanceGutHealthy controlsMicrobiomeDepressive disorder
2019
A Mechanistic Model of Gut–Brain Axis Perturbation and High-Fat Diet Pathways to Gut Microbiome Homeostatic Disruption, Systemic Inflammation, and Type 2 Diabetes
Lew K, Starkweather A, Cong X, Judge M. A Mechanistic Model of Gut–Brain Axis Perturbation and High-Fat Diet Pathways to Gut Microbiome Homeostatic Disruption, Systemic Inflammation, and Type 2 Diabetes. Biological Research For Nursing 2019, 21: 384-399. PMID: 31113222, DOI: 10.1177/1099800419849109.Peer-Reviewed Original ResearchConceptsGut-brain axisGut-brain axis pathwayHigh-fat dietDNA sequencing technologiesPro-inflammatory pathwaysMechanistic modelSequencing technologiesGut microbiomeHuman microbiomeHomeostatic disruptionProgression of T2DInsulin resistanceNonmodifiable risk factorsSystemic inflammationGutHigh-fatMicrobiomePathwayHomeostatic imbalanceMetabolic diseasesRisk factorsLow-grade systemic inflammationAmerican populationTranslocation of endotoxinWall permeability
2017
Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants
Xu W, Judge M, Maas K, Hussain N, McGrath J, Henderson W, Cong X. Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants. Journal Of Obstetric Gynecologic & Neonatal Nursing 2017, 47: 451-463. PMID: 29040820, PMCID: PMC5899689, DOI: 10.1016/j.jogn.2017.08.009.Peer-Reviewed Original ResearchConceptsPreterm infantsGut microbial communityEnteral feedingGut microbiotaEffects of enteral feedingGut microbiomeMicrobial communitiesBreast milk feedingInfant feeding typeMother's own milkGut microbial community structureInfant gut microbial communityDiversity of gut microbiotaSystematic reviewDonor human milkCochrane Database of Systematic ReviewsGut microbiome patternsDatabase of Systematic ReviewsELBW infantsPremature infantsMicrobial community structureSupplementation of prebioticsPretermEffects of probioticsFormula feedingInfluence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants
Cong X, Judge M, Xu W, Diallo A, Janton S, Brownell E, Maas K, Graf J. Influence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants. Nursing Research 2017, 66: 123-133. PMID: 28252573, PMCID: PMC5334772, DOI: 10.1097/nnr.0000000000000208.Peer-Reviewed Original ResearchConceptsGut microbial colonizationMother's own milkPreterm infantsGut microbiomeMicrobial diversityDiversity of gut microbiomeFeeding typeGut microbial diversityGut microbiome developmentGut microbiome compositionMicrobial community patternsAbundance of EnterobacterialesIncreased microbial diversityDevelopment of preterm infantsAbundance of ClostridialesNeonatal intensive care unitBirth gestational ageStable preterm infantsRRNA genePostnatal day 0Community patternsMicrobiome compositionIntensive care unitMicrobial patternsMicrobiome development
2016
Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors.
Cong X, Xu W, Romisher R, Poveda S, Forte S, Starkweather A, Henderson W. Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors. The Yale Journal Of Biology And Medicine 2016, 89: 299-308. PMID: 27698614, PMCID: PMC5045139.Peer-Reviewed Original ResearchConceptsGut microbiomeNeonatal intensive care unitDysbiosis of gut microbiotaSignaling systemHost-microbial interactionsNeonatal gut microbiomeGut microbiotaEvolutionary trajectoriesHigh-risk preterm infantsHost geneticsDysbiosis patternsLong-term infant healthIntensive care unitMicrobiomePreterm infantsEarly life stressGeneticsHuman newbornsRegulation of healthCare unitNeurodevelopmental processesInfant healthHostMedication useDelivery modeGut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender
Cong X, Xu W, Janton S, Henderson W, Matson A, McGrath J, Maas K, Graf J. Gut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender. PLOS ONE 2016, 11: e0152751. PMID: 27111847, PMCID: PMC4844123, DOI: 10.1371/journal.pone.0152751.Peer-Reviewed Original ResearchConceptsOperational taxonomic unitsGut microbiomeA-diversityGut microbiotaNeonatal intensive care unitPreterm infantsPatterns of gut microbiomeDiversity of gut microbiomeRRNA gene regionInfant gut microbiomeFeeding typeAbundance of EnterobacterialesGut microbiome patternsTaxonomic unitsAbundant phylumGene regionTotal readsAlpha diversityQIIME softwareV4 regionBacterial compositionDevelopmental patternsEarly lifeInfant's postnatal ageMicrobiome patterns
2015
Early Life Experience and Gut Microbiome
Cong X, Henderson W, Graf J, McGrath J. Early Life Experience and Gut Microbiome. Advances In Neonatal Care 2015, 15: 314-323. PMID: 26240939, PMCID: PMC4583334, DOI: 10.1097/anc.0000000000000191.Peer-Reviewed Original ResearchConceptsGut microbiomeHigh-risk infantsStressful early life experiencesCentral nervous systemSignaling systemPreterm infantsIntestinal innate immunityPain responseBrain-gut-microbiota axisNeonatal careEarly life experiencesNeuroimmune systemMicrobial speciesNervous systemInnate immunityRegulation mechanismInfantsGutMicrobiomeTargeted interventionsRegulationModulating stressPretermState-of-the-science reviewComplex mechanisms