2023
The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study
Chen J, Li H, Zhao T, Chen K, Chen M, Sun Z, Xu W, Maas K, Lester B, Cong X. The Impact of Early Life Experiences and Gut Microbiota on Neurobehavioral Development in Preterm Infants: A Longitudinal Cohort Study. Microorganisms 2023, 11: 814. PMID: 36985387, PMCID: PMC10056840, DOI: 10.3390/microorganisms11030814.Peer-Reviewed Original ResearchNeonatal intensive care unitNeonatal neurobehavioral scaleNeonatal intensive care unit hospitalizationOperational taxonomic unitsPreterm infantsPost-menstrual ageNeurobehavioral developmentGut microbiotaNeonatal intensive care unit admissionWeeks of post-menstrual ageFifty-five infantsDaily stool samplesIntensive care unitLongitudinal cohort studyImpact of early life experiencesNeurobehavioral ScalePretermPostnatal dayClinical featuresCohort studyEarly life experiencesStool samplesCare unitNeurobehavioral outcomesInfants
2015
Early Life Experience and Gut Microbiome
Cong X, Henderson W, Graf J, McGrath J. Early Life Experience and Gut Microbiome. Advances In Neonatal Care 2015, 15: 314-323. PMID: 26240939, PMCID: PMC4583334, DOI: 10.1097/anc.0000000000000191.Peer-Reviewed Original ResearchConceptsGut microbiomeHigh-risk infantsStressful early life experiencesCentral nervous systemSignaling systemPreterm infantsIntestinal innate immunityPain responseBrain-gut-microbiota axisNeonatal careEarly life experiencesNeuroimmune systemMicrobial speciesNervous systemInnate immunityRegulation mechanismInfantsGutMicrobiomeTargeted interventionsRegulationModulating stressPretermState-of-the-science reviewComplex mechanisms