2021
Pilot Study of Absolute Telomere Lengths in Preterm Infants
Casavant S, Li H, Reese B, Chen M, Cong X. Pilot Study of Absolute Telomere Lengths in Preterm Infants. Nursing Research 2021, 70: 481-486. PMID: 34173371, PMCID: PMC8563375, DOI: 10.1097/nnr.0000000000000535.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitPreterm infantsSample of preterm infantsAbsolute telomere lengthIncreased risk of neurodevelopmental disordersTelomere lengthAssociated with epigenetic alterationsRisk of neurodevelopmental disordersAssociated with painIntensive care unitPreterm infant samplesTime of dischargeBorn pretermInfant demographicsStudy of adultsAntibiotic usePretermPolymerase chain reactionPilot studyQuantitative polymerase chain reactionIncreased riskPainful proceduresShorter telomere lengthCare unitEpigenetic alterations
2019
Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review
Casavant S, Cong X, Moore J, Starkweather A. Associations between preterm infant stress, epigenetic alteration, telomere length and neurodevelopmental outcomes: A systematic review. Early Human Development 2019, 131: 63-74. PMID: 30870624, DOI: 10.1016/j.earlhumdev.2019.03.003.Peer-Reviewed Original ResearchMeSH KeywordsAngiomotinsBrain-Derived Neurotrophic FactorEpigenesis, GeneticHumansInfant, NewbornInfant, PrematureInsulin-Like Growth Factor IIIntensive Care Units, NeonatalIntercellular Signaling Peptides and ProteinsMembrane ProteinsMicrofilament ProteinsNeurodevelopmental DisordersNF-KappaB Inhibitor alphaReceptors, GlucocorticoidStress, PhysiologicalTacrolimus Binding ProteinsTelomereConceptsNeonatal intensive care unitPreterm infantsEpigenetic alterationsAssociated with increased riskLong-term outcome measuresTelomere erosionIntensive care unitBorn pretermTelomere lengthPreterm birthNeurodevelopmental outcomesPretermDisease entityPainful proceduresCare unitPreferred Reporting ItemsInfant stressHuman studiesLife-saving careTherapeutic interventionsOutcome measuresPsychiatric diseasesEarly detectionSystematic reviewReporting ItemsAllostatic Load and Biomarkers of Stress in the Preterm Infant: An Integrative Review
Casavant S, Cong X, Fitch R, Moore J, Rosenkrantz T, Starkweather A. Allostatic Load and Biomarkers of Stress in the Preterm Infant: An Integrative Review. Biological Research For Nursing 2019, 21: 210-223. PMID: 30654634, DOI: 10.1177/1099800418824415.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitPreterm infantsLong-term outcome measuresMarkers of oxidative stressIntensive care unitBorn pretermNociceptive inputNonnoxious stimuliBrain-gut-microbiome axisPretermPainful proceduresCare unitHuman studiesInclusion criteriaLife-saving careTherapeutic interventionsInfantsOutcome measuresEarly detectionTime pointsBiomarkersActivation of stress responsesCortisol levelsOxidative stressSystematic search