2023
Accelerated aging mediates the associations of unhealthy lifestyles with cardiovascular disease, cancer, and mortality
Li X, Cao X, Zhang J, Fu J, Mohedaner M, Danzengzhuoga, Sun X, Yang G, Yang Z, Kuo C, Chen X, Cohen A, Liu Z. Accelerated aging mediates the associations of unhealthy lifestyles with cardiovascular disease, cancer, and mortality. Journal Of The American Geriatrics Society 2023, 72: 181-193. PMID: 37789775, PMCID: PMC11078652, DOI: 10.1111/jgs.18611.Peer-Reviewed Original ResearchIncident cardiovascular diseaseCardiovascular diseaseUnhealthy lifestyleCause mortalityIncident cancerUK BiobankCox proportional hazards modelUnhealthy lifestyle scoreAssociation of lifestyleNutrition Examination SurveyUS National HealthProportional hazards modelAdverse health outcomesAge accelerationBiological age accelerationLifestyle interventionCVD mortalityLifestyle scoreExamination SurveyCancer mortalityBlood biomarkersMorbidity riskNational HealthMediation proportionHazards model
2019
Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study
Liu Z, Chen X, Gill TM, Ma C, Crimmins EM, Levine ME. Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study. PLOS Medicine 2019, 16: e1002827. PMID: 31211779, PMCID: PMC6581243, DOI: 10.1371/journal.pmed.1002827.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseasePhenotypic agingUS older adultsSelf-reported circumstancesRetirement StudyLife course circumstancesAssociation of geneticMorbidity riskMultivariable associationsPotential policy targetsRetrospective natureAdulthood circumstancesPhenotypic AgeAdulthood adversityGenetic predispositionHealth behaviorsSocioenvironmental circumstancesUS populationOlder adultsPotential interventionsDisadvantaged subpopulationsGenetic riskGenetic scoreUS Health