2020
Impact of Preoperative Lymphopenia on Survival Following Left Ventricular Assist Device Placement
Stawiarski K, Agboola O, Park J, Geirsson A, Jacoby D, Bellumkonda L, Ahmad T, Chou J, Lee F, Mangi A, Bonde P. Impact of Preoperative Lymphopenia on Survival Following Left Ventricular Assist Device Placement. ASAIO Journal 2020, 67: 650-657. PMID: 33074860, DOI: 10.1097/mat.0000000000001289.Peer-Reviewed Original ResearchConceptsAbsolute lymphocyte countCause mortalityLymphopenia groupLeft ventricular assist device patientsVentricular assist device patientsVentricular assist device placementCox proportional hazards modelImpact of lymphopeniaHeart failure populationKaplan-Meier plotsFurther clinical investigationProportional hazards modelLog-rank statisticsDurable LVADPreoperative lymphopeniaLVAD placementLymphocyte countLymphopenic patientsDevice patientsSingle centerPoor outcomePrognostic implicationsALC levelsFailure populationStudy population
2019
Improving Outcomes in INTERMACS 1 Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support
Mori M, McCloskey G, Geirsson A, Mangi AA, Yun JJ, Jacoby D, Ahmad T, Bellumkonda L, Lee F, Chen ME, Bonde P. Improving Outcomes in INTERMACS 1 Category 1 Patients with Pre-LVAD, Awake Venous-Arterial Extracorporeal Membrane Oxygenation Support. ASAIO Journal 2019, Publish Ahead of Print: &na;. PMID: 30664019, DOI: 10.1097/mat.0000000000000908.Peer-Reviewed Original ResearchConceptsCategory 1 patientsECMO supportDurable LVADECMO groupDurable left ventricular assist device implantationVenous-arterial extracorporeal membrane oxygenationLeft ventricular assist device implantationVentricular assist device implantationCox proportional hazards analysisExtracorporeal membrane oxygenation supportECMO-supported patientsPost-LVAD survivalVenous-arterial ECMOOutcomes of patientsAssist device implantationEnd-organ functionMembrane oxygenation supportProportional hazards analysisExtracorporeal membrane oxygenationRisk of deathINTERMACS scaleInteragency RegistryOxygenation supportECMO patientsUnadjusted survival
2018
Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients
Feher A, Srivastava A, Quail MA, Boutagy NE, Khanna P, Wilson L, Miller EJ, Liu YH, Lee F, Sinusas AJ. Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients. JACC Cardiovascular Imaging 2018, 13: 109-120. PMID: 30343093, PMCID: PMC6461525, DOI: 10.1016/j.jcmg.2018.08.025.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery DiseaseFemaleFractional Flow Reserve, MyocardialHeart TransplantationHumansMaleMiddle AgedMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsProspective StudiesRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesTime FactorsTreatment OutcomeConceptsPositron emission tomographyLong-term prognostic valueSerial assessmentPET-2Pet-1Cause mortalityHT patientsPrognostic valueHigh CFRLow CFRRb positron-emission tomographyEmission tomographyRb-82 positron emission tomographyRubidium-82 positron emission tomographyPET imagingHeart transplantation patientsHistory of HTCardiac allograft vasculopathyHeart transplant recipientsLong-term mortalitySingle-center studyMultivariate Cox regressionCoronary flow reserveAllograft vasculopathyHT recipients
2016
Cumulative stress and autonomic dysregulation in a community sample
Lampert R, Tuit K, Hong KI, Donovan T, Lee F, Sinha R. Cumulative stress and autonomic dysregulation in a community sample. Stress 2016, 19: 269-279. PMID: 27112063, PMCID: PMC5072401, DOI: 10.1080/10253890.2016.1174847.Peer-Reviewed Original ResearchConceptsHeart rate variabilityAdverse life eventsChronic stressLife eventsPoor cardiovascular outcomesChronic stressorsCardiac autonomic functionPrimary preventive strategiesAmbulatory ECG monitoringCumulative stress scoreRegression analysisLow-frequency powerNon-invasive measureRecent life eventsCumulative stressCardiovascular outcomesAutonomic functionAutonomic dysregulationPreventive strategiesNN intervalsAutonomic statusHealthy individualsHealth behaviorsECG monitoringRate variability
2010
Effects of Reiki on Autonomic Activity Early After Acute Coronary Syndrome
Friedman RS, Burg MM, Miles P, Lee F, Lampert R. Effects of Reiki on Autonomic Activity Early After Acute Coronary Syndrome. Journal Of The American College Of Cardiology 2010, 56: 995-996. PMID: 20828654, DOI: 10.1016/j.jacc.2010.03.082.Peer-Reviewed Original Research
2008
Pacemaker Therapy for Early and Late Sinus Node Dysfunction in Orthotopic Heart Transplant Recipients: A Single‐Center Experience
LUEBBERT JJ, LEE FA, ROSENFELD LE. Pacemaker Therapy for Early and Late Sinus Node Dysfunction in Orthotopic Heart Transplant Recipients: A Single‐Center Experience. Pacing And Clinical Electrophysiology 2008, 31: 1108-1112. PMID: 18834460, DOI: 10.1111/j.1540-8159.2008.01149.x.Peer-Reviewed Original ResearchConceptsOrthotopic heart transplantationSinus node dysfunctionOHT recipientsEarly complicationsTransplant recipientsLate sinus node dysfunctionSignificant sinus node dysfunctionOrthotopic heart transplant recipientsHeart transplant clinicMean age 50.2Heart transplant recipientsSingle-center experienceAge 50.2Electrophysiology serviceTransplant clinicHeart transplantationHeart transplantPermanent pacemakerLikely multifactorialPacemaker therapyLarge cohortPatientsAmbulatory monitoringRecipientsPacemaker
2007
Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes
Dewland TA, Androne AS, Lee FA, Lampert RJ, Katz SD. Effect of acetylcholinesterase inhibition with pyridostigmine on cardiac parasympathetic function in sedentary adults and trained athletes. AJP Heart And Circulatory Physiology 2007, 293: h86-h92. PMID: 17322413, DOI: 10.1152/ajpheart.01339.2006.Peer-Reviewed Original ResearchConceptsHeart rate recoveryPostexercise heart rate recoveryCardiac parasympathetic functionCardiac parasympathetic toneHeart rate variabilityRate recoveryParasympathetic toneSedentary adultsFrequency domain indicesHeart rateParasympathetic functionRate variabilityParasympathetic regulationSingle oral doseCardiac parasympathetic regulationExercise trainingCrossover trialOral doseParasympathetic pathwaysSedentary subjectsPyridostigmineHuman studiesPlaceboEfferent signalsAcetylcholinesterase inhibitors
2006
Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer
Abu-Khalaf MM, Juneja V, Chung GG, DiGiovanna MP, Sipples R, McGurk M, Zelterman D, Haffty B, Reiss M, Wackers FJ, Lee FA, Burtness BA. Long-term assessment of cardiac function after dose-dense and -intense sequential doxorubicin (A), paclitaxel (T), and cyclophosphamide (C) as adjuvant therapy for high risk breast cancer. Breast Cancer Research And Treatment 2006, 104: 341-349. PMID: 17051423, DOI: 10.1007/s10549-006-9413-7.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionEnd of chemotherapyEquilibrium radionuclide angiographyBreast cancerAdjuvant therapySequential doxorubicinCardiac functionIpsilateral axillary lymph nodesHigh-risk breast cancerRisk breast cancerClinical heart failureInitiation of chemotherapyAxillary lymph nodesVentricular ejection fractionEnd of therapyLong-term cardiotoxicityMedian absolute changeEligible patientsFilgrastim supportLate cardiotoxicityAxillary nodesAsymptomatic declineEjection fractionHeart failureLymph nodes
2005
Depressed autonomic nervous system function in African Americans and individuals of lower social class: A potential mechanism of race- and class-related disparities in health outcomes
Lampert R, Ickovics J, Horwitz R, Lee F. Depressed autonomic nervous system function in African Americans and individuals of lower social class: A potential mechanism of race- and class-related disparities in health outcomes. American Heart Journal 2005, 150: 153-160. PMID: 16084163, DOI: 10.1016/j.ahj.2004.08.008.Peer-Reviewed Original ResearchEffects of Psychologic Stress on Repolarization and Relationship to Autonomic and Hemodynamic Factors
LAMPERT R, SHUSTERMAN V, BURG MM, LEE FA, EARLEY C, GOLDBERG A, MCPHERSON CA, BATSFORD WP, SOUFER R. Effects of Psychologic Stress on Repolarization and Relationship to Autonomic and Hemodynamic Factors. Journal Of Cardiovascular Electrophysiology 2005, 16: 372-377. PMID: 15828878, DOI: 10.1046/j.1540-8167.2005.40580.x.Peer-Reviewed Original ResearchConceptsT-wave alternansMental stressVentricular arrhythmiasPsychological stressAmbulatory ECG monitoringT-wave amplitudePathophysiologic linkSusceptible patientsSystolic BPRepolarization indicesAlters indicesPsychologic stressRepolarization changesSudden deathPatientsHemodynamic factorsT-wave areaStress protocolECG monitoringArrhythmiasPhysiologic pathwaysRepolarizationMyocardial heterogeneityICDHr
2004
Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure
Upadya S, Lee FA, Saldarriaga C, Verma S, Sedrakyan A, Nystrom K, Katz SD. Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure. The Journal Of Heart And Lung Transplantation 2004, 23: 466-472. PMID: 15063407, DOI: 10.1016/s1053-2498(03)00203-1.Peer-Reviewed Original ResearchConceptsPositive inotropic therapyInotropic therapyCardiac transplantationFunctional capacityDecreased health care costsEnd-stage heart failureImplantable cardioverter-defibrillator dischargeHome therapy patientsStatus 1B patientsInitiation of therapyStable clinical statusNumber of hospitalizationsPre-treatment baselineImplantable cardioverter defibrillatorHealth care costsActuarial survivalInotropic treatmentRenal functionConsecutive patientsHeart failureClinical statusHemodynamic monitoringHome infusionInotropic infusionUnited Network
2003
Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial
Lampert R, Ickovics JR, Viscoli CJ, Horwitz RI, Lee FA. Effects of propranolol on recovery of heart rate variability following acute myocardial infarction and relation to outcome in the Beta-Blocker Heart Attack Trial. The American Journal Of Cardiology 2003, 91: 137-142. PMID: 12521623, DOI: 10.1016/s0002-9149(02)03098-9.Peer-Reviewed Original ResearchConceptsBeta-Blocker Heart Attack TrialAcute myocardial infarctionHeart rate variabilityPlacebo-treated patientsHeart Attack TrialMyocardial infarctionEffect of propranololBeta blockersAttack TrialDepressed heart rate variabilityRate variabilityRecovery of HRVLF/HF ratioPropranolol-treated patientsWeeks of treatmentHF ratioHigh-frequency powerPropranolol therapyPropranolol treatmentSympathetic predominanceAutonomic toneParasympathetic toneSympathovagal balanceImproved outcomesSudden death
2002
Heart rate variability during the week of September 11, 2001.
Lampert R, Baron SJ, McPherson CA, Lee FA. Heart rate variability during the week of September 11, 2001. JAMA 2002, 288: 575. PMID: 12150667, DOI: 10.1001/jama.288.5.575.Peer-Reviewed Original ResearchRacial Differences in the Use of Cardiac Procedures in Patients With Acute Myocardial Infarction
Funk M, Ostfeld AM, Chang VM, Lee FA. Racial Differences in the Use of Cardiac Procedures in Patients With Acute Myocardial Infarction. Nursing Research 2002, 51: 148-157. PMID: 12063413, DOI: 10.1097/00006199-200205000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAttitude of Health PersonnelBlack or African AmericanBlack PeopleChi-Square DistributionCohort StudiesConnecticutCoronary AngiographyFemaleHealth Services AccessibilityHumansLogistic ModelsMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationPatient TransferPrejudiceRetrospective StudiesWhite PeopleConceptsAcute myocardial infarctionUse of angiographyRevascularization proceduresMyocardial infarctionWhite patientsCardiac proceduresRacial differencesRegional cardiac referral centerCardiac referral centerRetrospective cohort studySubstantial racial differencesDemographic factorsObserved racial differencesConsecutive blacksCohort studyReferral centerCoronary angiographyBlack patientsClinical variablesMedical recordsOutlying hospitalsPatientsInfarctionAngiographyHospital
2001
Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients
Russell R, Chyun D, Song S, Sherwin R, Tamborlane W, Lee F, Pfeifer M, Rife F, Wackers F, Young L. Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients. AJP Endocrinology And Metabolism 2001, 281: e1029-e1036. PMID: 11595660, DOI: 10.1152/ajpendo.2001.281.5.e1029.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiac OutputCatecholaminesChemical PrecipitationDiabetes Mellitus, Type 1DiastoleEpinephrineFatty Acids, NonesterifiedFemaleGlucagonGlucose Clamp TechniqueHeartHeart RateHumansHydrocortisoneHypoglycemiaInsulinLactic AcidMaleNorepinephrinePolyethylene GlycolsStroke VolumeSystoleVentricular Function, LeftConceptsType 1 diabetic patientsInsulin-induced hypoglycemiaNondiabetic groupType 1 diabetesDiabetic subjectsEuglycemic hyperinsulinemiaDiabetic patientsNondiabetic subjectsCardiac responseLeft ventricular systolicHealthy nondiabetic subjectsEquilibrium radionuclide angiographyDiabetic groupDiastolic functionVentricular systolicCardiovascular consequencesVentricular functionBlunted increaseCardiac outputGlucagon concentrationsPlasma catecholaminesRadionuclide angiographyInsulin infusionEuglycemic conditionsHypoglycemia
2000
The feasibility of high-dose chemotherapy in breast cancer patients with impaired left ventricular function
Rose M, Lee F, Gollerkeri A, D'Andrea E, Psyrri A, Bdolah-Abram T, Burtness B. The feasibility of high-dose chemotherapy in breast cancer patients with impaired left ventricular function. Bone Marrow Transplantation 2000, 26: 133-139. PMID: 10918422, DOI: 10.1038/sj.bmt.1702449.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCombined Modality TherapyCyclophosphamideDoxorubicinFemaleFollow-Up StudiesHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationHumansMiddle AgedNeutropeniaPaclitaxelStroke VolumeSurvival RateVentricular Dysfunction, LeftConceptsLeft ventricular ejection fractionHigh-dose chemotherapyBreast cancer patientsMean absolute decreaseCancer patientsAbsolute decreaseLV functionCell rescueImpaired left ventricular functionHigh-dose thiotepaImpaired LV functionHigh-dose melphalanStem cell rescueSymptomatic heart failureCourses of chemotherapyVentricular ejection fractionLeft ventricular functionSequential paclitaxelMetastatic diseaseCardiac deathCardiac symptomsEjection fractionHeart failureVentricular functionCardiac toxicity
1996
Prognostic value of noninvasive testing one year after orthotopic cardiac transplantation
Verhoeven P, Lee F, Ramahi T, Franco K, de Leon C, Amatruda J, Gorham N, Mattera J, Wackers F. Prognostic value of noninvasive testing one year after orthotopic cardiac transplantation. Journal Of The American College Of Cardiology 1996, 28: 183-189. PMID: 8752812, DOI: 10.1016/0735-1097(96)00094-0.Peer-Reviewed Original ResearchConceptsCoronary artery vasculopathyOrthotopic cardiac transplantationCardiac transplantationEquilibrium radionuclide angiographyPrognostic valueRadionuclide angiographyClinical variablesNoninvasive testingHuman leukocyte antigen mismatchesStress thallium-201 imagingThallium-201 myocardial perfusion imagingConsecutive transplant recipientsRoutine noninvasive testingStress myocardial imagingCold ischemic timeStress myocardial perfusionThallium-201 imagingTwo-dimensional echocardiographyNoninvasive diagnostic testingMyocardial perfusion imagingOnly significant predictorAntigen mismatchesLate deathsTransplant recipientsIschemic time
1995
Optimal timing and indications for cholecystectomy in cardiac transplant patients
Begos D, Franco K, Baldwin J, Lee F, Revkin J, Modlin I. Optimal timing and indications for cholecystectomy in cardiac transplant patients. World Journal Of Surgery 1995, 19: 661-667. PMID: 7676717, DOI: 10.1007/bf00294752.Peer-Reviewed Original ResearchConceptsCardiac transplantSeptic complicationsTransplant patientsEnd-stage cardiac diseaseCases of cholecystectomyPostcardiac transplant patientsCardiac transplant patientsStandard management approachType of procedureAsymptomatic calculiElective cholecystectomyPosttransplant groupsPosttransplant surveillancePretransplant groupPretransplant screeningUncontrollable arrhythmiaUrgent cholecystectomyAcute cholecystitisCardiac transplantationPosttransplant patientsPretransplant patientsHeart transplantSuch patientsTransplant centersCardiac risk
1994
Circadian variation of sustained ventricular tachycardia in patients with coronary artery disease and implantable cardioverter-defibrillators.
Lampert R, Rosenfeld L, Batsford W, Lee F, McPherson C. Circadian variation of sustained ventricular tachycardia in patients with coronary artery disease and implantable cardioverter-defibrillators. Circulation 1994, 90: 241-247. PMID: 8026004, DOI: 10.1161/01.cir.90.1.241.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSustained ventricular tachycardiaVentricular tachycardiaArtery diseaseCircadian variationVT occurrenceSudden deathMechanism of VTLife-threatening ventricular tachycardiaEpisodes of VTAmbulatory ECG monitoringConsecutive patientsEjection fractionDrug therapyIndividual patientsEpidemiological dataPatientsTachycardiaECG monitoringCircadian patternDiseaseArrhythmiasDeathInfrequent eventEpisodes