2013
Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3
Geahlen JH, Lapid C, Thorell K, Nikolskiy I, Huh WJ, Oates EL, Lennerz JK, Tian X, Weis VG, Khurana SS, Lundin SB, Templeton AR, Mills JC. Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3. Physiological Genomics 2013, 45: 667-683. PMID: 23715263, PMCID: PMC3742967, DOI: 10.1152/physiolgenomics.00169.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsComputational BiologyDNA PrimersEvolution, MolecularFluorescent Antibody TechniqueGastric MucosaGenetic LociGenetics, PopulationGenotypeHaplotypesHumansLikelihood FunctionsMacaca mulattaMembrane ProteinsMiceMice, Inbred C57BLMicroarray AnalysisMicroscopy, ConfocalModels, GeneticMutationPhylogenyPolymorphism, Single NucleotidePseudogenesRacial GroupsSelection, GeneticSpecies SpecificitySus scrofaConceptsSelective sweepsHuman genetic locusGenome evolutionGenomic neighborsSplice donor siteDirectional selectionHuman genomeGenetic lociBp downstreamEuropean genesGKN3Gastric mucous neck cellsStop codon mutationThird memberHuman populationGenesCodon mutationLociGKN2Haplotype analysisMucous neck cellsMutationsAfrican populationsNeck cellsGKN1
2010
The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma
Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. The Transcription Factor MIST1 Is a Novel Human Gastric Chief Cell Marker Whose Expression Is Lost in Metaplasia, Dysplasia, and Carcinoma. American Journal Of Pathology 2010, 177: 1514-1533. PMID: 20709804, PMCID: PMC2928982, DOI: 10.2353/ajpath.2010.100328.Peer-Reviewed Original ResearchConceptsChief cellsTranscription factor MIST1Gastric carcinogenesisMIST1 expressionSimilar progressive lossChief cell lineagesNormal oxyntic mucosaHuman gastric carcinogenesisHuman chief cellsChief cell markersIntestinal metaplasiaCell carcinomaMetaplastic lesionsResection specimensGastric adenocarcinomaPrecursor lesionsOxyntic mucosaTissue microarrayMetaplasiaMurine dataReliable markerTFF2 expressionHuman lesionsCell markersComparison of findings