Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach
Huh WJ, Khurana SS, Geahlen JH, Kohli K, Waller RA, Mills JC. Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach. Gastroenterology 2011, 142: 21-24.e7. PMID: 22001866, PMCID: PMC3708546, DOI: 10.1053/j.gastro.2011.09.050.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAtrophyChief Cells, GastricFemaleGene Expression RegulationInjections, IntraperitonealIntegrasesLac OperonMaleMetaplasiaMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicParietal Cells, GastricSelective Estrogen Receptor ModulatorsSpecies SpecificityTamoxifenTime FactorsConceptsSelective estrogen receptor modulatorsParietal cellsBody weight doseEstrogen receptor modulatorsTamoxifen side effectsAcid secretion inhibitionZymogenic chief cellsReversible atrophyWeight doseGastric toxicityIntraperitoneal administrationReceptor modulatorsNormal miceSide effectsSecretion inhibitionGastric parietal cellsChief cellsMouse stomachTamoxifenMetaplasiaMultiple strainsToxicityCellsPatientsAtrophy