1990
Release of a neutrophil‐derived vascoconstrictor agent which augments platelet‐induced contractions of blood vessels in vitro
Sessa W, Mullane K. Release of a neutrophil‐derived vascoconstrictor agent which augments platelet‐induced contractions of blood vessels in vitro. British Journal Of Pharmacology 1990, 99: 553-559. PMID: 2110018, PMCID: PMC1917347, DOI: 10.1111/j.1476-5381.1990.tb12967.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicBlood PlateletsCalcimycinIn Vitro TechniquesLipoxygenase InhibitorsMaleMolecular WeightMuscle ContractionMuscle TonusMuscle, Smooth, VascularN-Formylmethionine Leucyl-PhenylalanineNeutrophilsRabbitsSerotoninSerotonin AntagonistsTetradecanoylphorbol AcetateVasoconstrictor AgentsConceptsContractile factorsVascular toneBlood vesselsEnd-organ antagonistNeutrophil-derived productsPlatelet-induced contractionsConcentration-dependent contractionsInhibition of contractionRat stomach stripCyclo-oxygenase enzymeTimes more plateletsRabbit thoracic aortaPhorbol myristate acetateFree radical scavengerContractile responseInhibitors of lipoxygenaseOrgan bathAngiotensin IIReceptor antagonistStomach stripIntact endotheliumNeutrophil activationThoracic aortaActivated neutrophilsDesArg9-bradykinin
1987
Myocardial Salvage Induced by REV-5901
Mullane K, Hatala M, Kraemer R, Sessa W, Westlin W. Myocardial Salvage Induced by REV-5901. Journal Of Cardiovascular Pharmacology 1987, 10: 398-406. PMID: 2444792, DOI: 10.1097/00005344-198710000-00004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachidonate LipoxygenasesDogsHydroxyquinolinesLeukotriene B4Lipoxygenase InhibitorsMaleMyocardial InfarctionNeutrophilsQuinolinesRabbitsSRS-AConceptsCoronary artery occlusionArtery occlusionInfarct sizeEnd-organ antagonistLeukotriene-like materialAccumulation of neutrophilsLeukotriene B4 generationSelective cyclooxygenase inhibitorsLeukotriene B4 formationSpasmogenic effectNeutrophil accumulationHemodynamic effectsHypoperfused zoneMyocardial injuryMyocardial salvageCardiac damageIschemic myocardiumB4 generationAnesthetized dogsCyclooxygenase inhibitorIschemic heartB4 formationCyclooxygenase enzymesCanine neutrophilsLipoxygenase metabolites