2022
Targeting the vasculature in cardiometabolic disease
Boutagy NE, Singh AK, Sessa WC. Targeting the vasculature in cardiometabolic disease. Journal Of Clinical Investigation 2022, 132: e148556. PMID: 35289308, PMCID: PMC8920329, DOI: 10.1172/jci148556.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiometabolic diseasesCardiometabolic disease burdenOptimal medical therapyType 2 diabetesContext of atherosclerosisCardiometabolic changesCV morbidityEndothelial dysfunctionEjection fractionGlycemic controlHeart failureMedical therapyProinflammatory mediatorsVascular inflammationDisease burdenDisease progressionCardiovascular diseaseVascular remodelingPathological changesEpidemic proportionsVascular endotheliumMetabolic diseasesDiseaseVasculatureObesity
2000
Temporal Events Underlying Arterial Remodeling After Chronic Flow Reduction in Mice
Rudic R, Bucci M, Fulton D, Segal S, Sessa W. Temporal Events Underlying Arterial Remodeling After Chronic Flow Reduction in Mice. Circulation Research 2000, 86: 1160-1166. PMID: 10850968, DOI: 10.1161/01.res.86.11.1160.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarotid Artery, CommonCell DeathDrug CombinationsIn Vitro TechniquesMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIRegional Blood FlowTime FactorsTunica MediaVasodilator AgentsVasomotor SystemConceptsLeft common carotid arteryRight common carotid arteryCommon carotid arteryCarotid arteryBlood flowLeft external carotid arteryEndothelial NO synthase (eNOS) functionEndothelial NO synthase (eNOS) mRNAExternal carotid arteryNO synthase mRNANitrovasodilator sodium nitroprussideAcute ligationEndothelial dysfunctionArterial remodelingControl arteriesVascular remodelingAdult miceSodium nitroprussideDay 7Structural remodelingArteryLuminal remodelingMarked reductionProtein levelsMiceChapter 9 Molecular Control of Endothelial Derived Nitric Oxide A New Paradigm for Endothelial NOS Regulation by Posttranslational Modifications
Gratton J, Fontana J, Sessa W. Chapter 9 Molecular Control of Endothelial Derived Nitric Oxide A New Paradigm for Endothelial NOS Regulation by Posttranslational Modifications. 2000, 157-166. DOI: 10.1016/b978-012370420-7/50010-1.Peer-Reviewed Original ResearchNitric oxideEndothelial NOSVascular remodelingEndothelium-derived relaxing factorsEndothelium-derived nitric oxideEndothelial nitric oxide synthase regulationBlood pressure controlNitric oxide synthase regulationRelaxing factorsVasomotor controlCardiovascular homeostasisNOS isoformsVascular endotheliumVascular biologyNOS regulationPhysiological productionPosttranslational control mechanismsFamily membersAngiogenesisProfound perturbationRemodelingPosttranslational modificationsMolecular controlThrombosisInflammation
1999
Nitric Oxide in Endothelial Dysfunction and Vascular Remodeling: Clinical Correlates and Experimental Links
Rudic R, Sessa W. Nitric Oxide in Endothelial Dysfunction and Vascular Remodeling: Clinical Correlates and Experimental Links. American Journal Of Human Genetics 1999, 64: 673-677. PMID: 10052999, PMCID: PMC1377782, DOI: 10.1086/302304.Peer-Reviewed Original Research