2006
Caveolin‐1 regulation of experimental colitis
Greer J, Chidlow J, Bernatchez P, Sessa W, Shukla D, Kevil C. Caveolin‐1 regulation of experimental colitis. The FASEB Journal 2006, 20: a1378-a1378. DOI: 10.1096/fasebj.20.5.a1378.Peer-Reviewed Original ResearchDisease activity indexExperimental colitisAP-CavDextran sulfate sodium (DSS) modelWild-type control miceDSS-Induced ColitisInflammatory bowel diseaseCaveolin-1Degree of inflammationWild-type miceWild-type colonAB peptideGross bleedingTransmural inflammationInduced colitisMicrovascular dysfunctionStool consistencyBowel diseaseMicrovascular functionLymphoplasmacytic infiltrateOccult bloodControl miceHistopathology scoresInflammatory responseColitis
1992
High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis
Murch SH, Braegger CP, MacDonald T, Sessa W. High endothelin-1 immunoreactivity in Crohn's disease and ulcerative colitis. The Lancet 1992, 339: 381-385. PMID: 1346658, DOI: 10.1016/0140-6736(92)90077-g.Peer-Reviewed Original ResearchConceptsCrohn's disease patientsInflammatory bowel diseaseDisease patientsUlcerative colitisCrohn's diseaseBowel diseaseEndothelin-1Lamina propriaChronic inflammatory bowel diseaseEndothelin-1 immunoreactivitySubmucosal blood vesselsUlcerative colitis patientsTissue samplesUlcerative colitis groupEndothelin concentrationsImmunological hypersensitivityIntestinal ischaemiaColitis groupColitis patientsEndothelin productionInflammatory cellsPotent vasoconstrictorVascular abnormalitiesDisease groupImmunoreactive cells