1998
PTHrP Regulates Epidermal Differentiation in Adult Mice
Foley J, Wysolmerski J, Dreyer B, Broadus A, Philbrick W, Longely B. PTHrP Regulates Epidermal Differentiation in Adult Mice. Journal Of Investigative Dermatology 1998, 111: 1122-1128. PMID: 9856827, DOI: 10.1046/j.1523-1747.1998.00428.x.Peer-Reviewed Original ResearchConceptsPTHrP-knockout miceKeratin 14 promoterAdult miceSebaceous glandsHuman keratin 14 promoterParathyroid hormone-related peptideHyperplastic sebaceous glandsHormone-related peptideAbsence of PTHrPNumber of organsWk of agePremature acquisitionEpidermal proliferation rateMarked acanthosisTransgenic replacementReciprocal findingsTransgenic micePTHrPPTHrP geneMiceMammary glandBasal keratinocytesDisplay abnormalitiesLethal chondrodystrophyFibrotic dermisParathyroid hormone‐related protein is a developmental regulatory molecule
Philbrick W. Parathyroid hormone‐related protein is a developmental regulatory molecule. European Journal Of Oral Sciences 1998, 106: 32-37. PMID: 9541200, DOI: 10.1111/j.1600-0722.1998.tb02150.x.Peer-Reviewed Original ResearchConceptsDevelopmental regulatory moleculeOverexpression of PTHrPHormone-related proteinHormone-related peptideSingle G protein-coupled receptorG protein-coupled receptorsProtein-coupled receptorsPTHrP overexpressionHumoral hypercalcemiaTumor productsPTHrP functionsKnockout miceMammary epithelial cellsTransgenic miceRegulatory moleculesMiceEpithelial cellsPTH geneRegulatory effectsPTHrPN-terminal productType IMultiple tissuesConvincing evidenceOverexpression
1996
Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.
Weir E, Philbrick W, Amling M, Neff L, Baron R, Broadus A. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 10240-10245. PMID: 8816783, PMCID: PMC38368, DOI: 10.1073/pnas.93.19.10240.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone DevelopmentDwarfismGene Expression Regulation, DevelopmentalGrowth PlateHumansMiceMice, Inbred C57BLMice, Inbred StrainsMice, TransgenicOsteochondrodysplasiasParathyroid HormoneParathyroid Hormone-Related ProteinPolymerase Chain ReactionProcollagenPromoter Regions, GeneticProtein BiosynthesisProteinsRegulatory Sequences, Nucleic AcidTranscription, GeneticConceptsPTH/PTHrP receptorHormone-related peptideParathyroid hormonePTHrP receptorParathyroid hormone-related peptideChondrocyte differentiationOverexpression of PTHrPType II collagen promoterEndochondral ossificationShort-limbed dwarfismParaneoplastic hypercalcemiaPTHrP functionsBone collar formationMalignant tumorsDevelopmental regulatory moleculeEndochondral bone formationTransgenic micePTHrPCommon receptorEndochondral bone developmentTargeted overexpressionFetal tissuesPTHrP geneFollicle formationNormal boneOverexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia (∗)
Vasavada R, Cavaliere C, D'Ercole A, Dann P, Burtis W, Madlener A, Zawalich K, Zawalich W, Philbrick W, Stewart A. Overexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia (∗). Journal Of Biological Chemistry 1996, 271: 1200-1208. PMID: 8557651, DOI: 10.1074/jbc.271.2.1200.Peer-Reviewed Original ResearchConceptsRat insulin II promoterInsulin secretionIslet massPancreatic isletsNormal littermatesHormone-related proteinBlood glucose valuesTotal islet massIslet perifusion studiesNormal physiologic roleInappropriate hyperinsulinemiaParathyroid hormoneIslet hyperplasiaInsulin concentrationsTotal islet numberAutocrine roleGlucose homeostasisPerifusion studiesTransgenic miceGlucose valuesIslet numberIslet cellsPhysiologic rolePTHrPMice