2017
Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders
Puleo DE, Kucera K, Hammarén H, Ungureanu D, Newton AS, Silvennoinen O, Jorgensen WL, Schlessinger J. Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. ACS Medicinal Chemistry Letters 2017, 8: 618-621. PMID: 28626521, PMCID: PMC5467198, DOI: 10.1021/acsmedchemlett.7b00153.Peer-Reviewed Original ResearchSmall molecule bindersJAK2 pseudokinase domainKinase foldTyrosine kinase domainNovel pharmacological opportunitiesPseudokinase domainKinase domainJAK-STATJAK2 proteinTop hitsMicromolar affinityPharmacological opportunitiesHyperactivation stateProteinATPJH2JAK2 V617FRecent evidencePseudokinaseMutantsJAKDomainHematopoiesisPathwayStructural approach
2010
Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening
Ravindranathan KP, Mandiyan V, Ekkati AR, Bae JH, Schlessinger J, Jorgensen WL. Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening. Journal Of Medicinal Chemistry 2010, 53: 1662-1672. PMID: 20121196, PMCID: PMC2842983, DOI: 10.1021/jm901386e.Peer-Reviewed Original ResearchConceptsFibroblast growth factorCo-crystal structureKinase structureFGFR1 kinaseSearch of inhibitorsEmbryonic developmentProtein structureAlternative conformationsCell proliferationStructural motifsKinase inhibitorsGrowth factorNew structural motifDiverse compoundsVirtual screeningFGFR1InhibitorsDockingWound healingThienopyrimidinone derivativesImportant roleConformationKinaseProteinMotif