2019
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou X, Chen G, Bracamonte-Baran W, Choi H, Diny N, Sung J, Hughes D, Won T, Wood M, Talor M, Hackam D, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin J, Čiháková D. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Reports 2019, 28: 172-189.e7. PMID: 31269438, PMCID: PMC6813836, DOI: 10.1016/j.celrep.2019.06.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyCell DifferentiationCell ProliferationC-Mer Tyrosine KinaseDisease Models, AnimalFibroblastsHumansInflammationInterleukin-17MacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, Electron, TransmissionMonocytesMyocarditisMyocardiumParabiosisSignal TransductionTranscriptomeConceptsExperimental autoimmune myocarditisMonocyte-derived macrophagesIL-17AHeart failureCardiac fibroblastsMurine experimental autoimmune myocarditisIL-17A levelsMacrophage differentiationAutoimmune myocarditisAcute phaseCardiac fibrosisClinical correlationReceptor expressionLy6CMonocyte fateTypes of monocytesMacrophagesMyocarditisMHCIIMonocytesFibroblastsSupDifferentiationFibrosisSequalae
2018
Sca‐1+ cardiac fibroblasts promote development of heart failure
Chen G, Bracamonte‐Baran W, Diny N, Hou X, Talor M, Fu K, Liu Y, Davogustto G, Vasquez H, Taegtmeyer H, Frazier O, Waisman A, Conway S, Wan F, Čiháková D. Sca‐1+ cardiac fibroblasts promote development of heart failure. European Journal Of Immunology 2018, 48: 1522-1538. PMID: 29953616, PMCID: PMC6696927, DOI: 10.1002/eji.201847583.Peer-Reviewed Original ResearchConceptsHeart failureCardiac fibroblastsGM-CSFCardiac inflammationIL-17AFibroblast subsetsSca-1Post-infarct heart failureMyocardial infarction mouse modelExperimental autoimmune myocarditisHeart failure patientsCytokine production profileCardiac biopsy samplesAutoimmune myocarditisIschemic originFailure patientsIschemic cardiomyopathyInflammatory Ly6CImmune cellsMouse modelFl/Biopsy samplesMyocarditisMouse heartsSpecific ablation