2020
Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression
Jurcova I, Rocek J, Bracamonte‐Baran W, Zelizko M, Netuka I, Maluskova J, Kautzner J, Cihakova D, Melenovsky V, Maly J. Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression. ESC Heart Failure 2020, 7: 1976-1981. PMID: 32485066, PMCID: PMC7373888, DOI: 10.1002/ehf2.12697.Peer-Reviewed Original ResearchConceptsMechanical circulatory supportCirculatory supportT cell-mediated myocarditisTemporary mechanical circulatory supportThird-degree atrioventricular blockWeeks of supportSevere biventricular failureT-cell predominanceExtracorporeal membrane oxygenationPrevious cardiac historyBiventricular failureCardiogenic shockVentricular dysfunctionLymphocytic myocarditisCardiac historyEndomyocardial biopsyMembrane oxygenationAtrioventricular blockVentricular unloadingMacrophage expansionMyocarditisFlow cytometryComplete recoverySustained recoveryImmunosuppression
2019
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou X, Chen G, Bracamonte-Baran W, Choi H, Diny N, Sung J, Hughes D, Won T, Wood M, Talor M, Hackam D, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin J, Čiháková D. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Reports 2019, 28: 172-189.e7. PMID: 31269438, PMCID: PMC6813836, DOI: 10.1016/j.celrep.2019.06.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyCell DifferentiationCell ProliferationC-Mer Tyrosine KinaseDisease Models, AnimalFibroblastsHumansInflammationInterleukin-17MacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, Electron, TransmissionMonocytesMyocarditisMyocardiumParabiosisSignal TransductionTranscriptomeConceptsExperimental autoimmune myocarditisMonocyte-derived macrophagesIL-17AHeart failureCardiac fibroblastsMurine experimental autoimmune myocarditisIL-17A levelsMacrophage differentiationAutoimmune myocarditisAcute phaseCardiac fibrosisClinical correlationReceptor expressionLy6CMonocyte fateTypes of monocytesMacrophagesMyocarditisMHCIIMonocytesFibroblastsSupDifferentiationFibrosisSequalae
2018
Sca‐1+ cardiac fibroblasts promote development of heart failure
Chen G, Bracamonte‐Baran W, Diny N, Hou X, Talor M, Fu K, Liu Y, Davogustto G, Vasquez H, Taegtmeyer H, Frazier O, Waisman A, Conway S, Wan F, Čiháková D. Sca‐1+ cardiac fibroblasts promote development of heart failure. European Journal Of Immunology 2018, 48: 1522-1538. PMID: 29953616, PMCID: PMC6696927, DOI: 10.1002/eji.201847583.Peer-Reviewed Original ResearchConceptsHeart failureCardiac fibroblastsGM-CSFCardiac inflammationIL-17AFibroblast subsetsSca-1Post-infarct heart failureMyocardial infarction mouse modelExperimental autoimmune myocarditisHeart failure patientsCytokine production profileCardiac biopsy samplesAutoimmune myocarditisIschemic originFailure patientsIschemic cardiomyopathyInflammatory Ly6CImmune cellsMouse modelFl/Biopsy samplesMyocarditisMouse heartsSpecific ablation
2017
Cardiac Autoimmunity: Myocarditis
Bracamonte-Baran W, Čiháková D. Cardiac Autoimmunity: Myocarditis. Advances In Experimental Medicine And Biology 2017, 1003: 187-221. PMID: 28667560, PMCID: PMC5706653, DOI: 10.1007/978-3-319-57613-8_10.Peer-Reviewed Original ResearchConceptsAutoimmune processAdaptive T cell responsesGiant cell myocarditisT cell responsesVariable clinical presentationMonocytes/macrophagesImmunopathogenic featuresAcute complicationsAutoimmune myocarditisSystolic dysfunctionAcute myocarditisCryptic antigensHemodynamic complicationsHeart failureTreg inductionClinical presentationElectrophysiologic disturbancesHumoral responseClinical correlatesDifferent etiologiesInflammatory processImmune responseMyocarditisSpecific cytokinesChronic damage