2017
Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance
Bracamonte-Baran W, Florentin J, Zhou Y, Jankowska-Gan E, Haynes W, Zhong W, Brennan T, Dutta P, Claas F, van Rood J, Burlingham W. Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 1099-1104. PMID: 28096390, PMCID: PMC5293109, DOI: 10.1073/pnas.1618364114.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsB7-2 AntigenB7-H1 AntigenCD4-Positive T-LymphocytesChimerismDendritic CellsExtracellular VesiclesFemaleFetomaternal TransfusionH-2 AntigensHistocompatibility Antigen H-2DHistocompatibility Antigens Class IIImmune ToleranceIsoantigensMaleMaternal-Fetal ExchangeMiceMice, Inbred C57BLMice, TransgenicModels, ImmunologicalPregnancyT-Cell Antigen Receptor SpecificityConceptsHost dendritic cellsCD4 T cellsDendritic cellsPD-L1Maternal microchimerismT cellsMyeloid DCsPlasmacytoid DCsMHC alloantigensTransgenic CD4 T cellsMyeloid dendritic cellsPlasmacytoid dendritic cellsExtracellular vesiclesAdoptive transferAntitumor immunityMaternal antigensTransplant toleranceTumor immunityMurine modelSerum EVsPhysiologic linkMHC complexesMiceSerum fractionsMode of action
2016
Kinetics of Alloantigen-Specific Regulatory CD4 T Cell Development and Tissue Distribution After Donor-Specific Transfusion and Costimulatory Blockade
Tomita Y, Satomi M, Bracamonte-Baran W, Jankowska Gan E, Workman A, Workman C, Vignali D, Burlingham W. Kinetics of Alloantigen-Specific Regulatory CD4 T Cell Development and Tissue Distribution After Donor-Specific Transfusion and Costimulatory Blockade. Transplantation Direct 2016, 2: e73. PMID: 27500263, PMCID: PMC4946513, DOI: 10.1097/txd.0000000000000580.Peer-Reviewed Original ResearchCD4 T cellsDonor-specific transfusionRegulatory T cellsTreg cell subsetsT cellsCell subsetsLymphoid tissueTissue-resident memory T cellsCD4 T cell developmentDouble reporter miceMemory T cellsSecondary lymphoid organsT cell developmentCD40L blockadeRecipient antigensTrans vivoCostimulatory blockadeCytokine IL10Graft outcomeTreg cellsTransplant toleranceAllospecific responsesLymphoid organsDonor organsReporter mice