2016
Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses
Li W, Avey D, Fu B, Wu J, Ma S, Liu X, Zhu F. Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses. Journal Of Virology 2016, 90: 5329-5342. PMID: 27009954, PMCID: PMC4934757, DOI: 10.1128/jvi.02675-15.Peer-Reviewed Original ResearchConceptsKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusImmune evasion functionsViral particlesKSHV replicationTegument proteinsInfectious progeny virusInfectious viral particlesPrimary infectionSpecific monoclonal antibodiesExtracellular virionsViral life cycleImmune evasionKSHV life cycleTherapeutic interventionsViral replicationNovel targetKSHV lytic replicationMonoclonal antibodiesCytosolic DNAReduced virion productionLytic replicationProgeny virusVirion proteinsVirion production
2015
Mono-ubiquitylated ORF45 Mediates Association of KSHV Particles with Internal Lipid Rafts for Viral Assembly and Egress
Wang X, Zhu N, Li W, Zhu F, Wang Y, Yuan Y. Mono-ubiquitylated ORF45 Mediates Association of KSHV Particles with Internal Lipid Rafts for Viral Assembly and Egress. PLOS Pathogens 2015, 11: e1005332. PMID: 26650119, PMCID: PMC4674120, DOI: 10.1371/journal.ppat.1005332.Peer-Reviewed Original ResearchKaposi's sarcoma-associated herpesvirusLipid raftsSarcoma-associated herpesvirusFinal envelopmentVesicle membraneRecombinant Kaposi's sarcoma-associated herpesvirusTrans-Golgi networkCytoplasmic membrane vesiclesCellular cargo transportVirion particlesInfectious virion particlesHost cell membraneViral particlesTrans-GolgiEndosome vesiclesLR associationBudding processORF45Virion assemblyWild typeIntracellular signalingTegument proteinsCellular membranesMembrane vesiclesViral assembly