A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo
Zhou W, Wu J, Wu Q, Wang J, Zhou Y, Zhou R, He P, Li X, Yang Y, Zhang Y, Li Y, Zuo J. A novel artemisinin derivative, 3-(12-β-artemisininoxy) phenoxyl succinic acid (SM735), mediates immunosuppressive effects in vitro and in vivo. Acta Pharmacologica Sinica 2005, 26: 1352-1358. PMID: 16225758, DOI: 10.1111/j.1745-7254.2005.00232.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory Agents, Non-SteroidalArtemisininsCell ProliferationCells, CulturedCytokinesDose-Response Relationship, DrugHemolysisHypersensitivity, DelayedImmunosuppressive AgentsInhibitory Concentration 50Interferon-gammaInterleukin-12Lymphocyte Culture Test, MixedMaleMiceMice, Inbred BALB CMice, Inbred C57BLSuccinatesConceptsDelayed-type hypersensitivityMixed lymphocyte reactionProliferation of splenocytesSheep red blood cellsImmunosuppressive agentsCytokine productionT-cell-mediated delayed-type hypersensitivityImmunosuppressive activityVivo immune activityProinflammatory cytokine productionIL-2 secretionNovel artemisinin derivativesEnzyme-linked immunosorbentDose-dependent mannerStrong immunosuppressive activityPotential immunosuppressive agentsRed blood cellsLymphocyte reactionImmunosuppressive effectsQuantitative hemolysisImmune activityMouse modelArtemisinin derivativesConA stimulationBlood cellsSynthesis and Immunosuppressive Activity of New Artemisinin Derivatives. 1. [12(β or α)-Dihydroartemisininoxy]phen(ox)yl Aliphatic Acids and Esters
Yang Z, Zhou W, Sui Y, Wang J, Wu J, Zhou Y, Zhang Y, He P, Han J, Tang W, Li Y, Zuo J. Synthesis and Immunosuppressive Activity of New Artemisinin Derivatives. 1. [12(β or α)-Dihydroartemisininoxy]phen(ox)yl Aliphatic Acids and Esters. Journal Of Medicinal Chemistry 2005, 48: 4608-4617. PMID: 15999998, DOI: 10.1021/jm048979c.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationArtemisininsB-LymphocytesCell ProliferationConcanavalin ADinitrofluorobenzeneErythrocytesEstersFatty AcidsFemaleHypersensitivity, DelayedImmunosuppressive AgentsIn Vitro TechniquesLipopolysaccharidesMaleMiceMice, Inbred BALB CMitogensSesquiterpenesSheepStructure-Activity RelationshipT-LymphocytesConceptsB cell proliferationSheep red blood cellsT cell proliferationCell proliferationImmunosuppressive activityDelayed-type hypersensitivity reactionCytotoxicity of lymphocytesNew artemisinin derivativesPotential immunosuppressive agentsRed blood cellsImmunosuppressive agentsHypersensitivity reactionsT cellsInhibition activityArtemisinin derivativesAntibody productionCyclosporin ADihydroartemisinin derivativesBlood cellsInhibitory effectHigh efficacyLipopolysaccharideConcanavalin AProliferationHighest inhibition activity