B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb
Nie X, Chen W, Zhu Y, Huang B, Yu W, Wu Z, Guo S, Zhu Y, Luo L, Wang S, Chen L. B7-DC (PD-L2) costimulation of CD4+ T-helper 1 response via RGMb. Cellular & Molecular Immunology 2017, 15: 888-897. PMID: 28479601, PMCID: PMC6207567, DOI: 10.1038/cmi.2017.17.Peer-Reviewed Original ResearchConceptsRepulsive guidance molecule bT cell responsesB7-DCPD-1T cellsB7-DC/PDCoinhibitory receptor PD-1T helper 1 responseTh2-mediated asthmaSmall airway inflammationReceptor PD-1T cell inhibitionExperimental mouse modelNaive mouse T cellsMouse T cellsAirway inflammationTh1 polarizationTh1 responseDendritic cellsLung pathologyMouse modelCostimulatory functionCostimulatory receptorsCD4Costimulation