2023
Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials
Khetrapal P, Wong J, Tan W, Rupasinghe T, Tan W, Williams S, Boorjian S, Wijburg C, Parekh D, Wiklund P, Vasdev N, Khan M, Guru K, Catto J, Kelly J. Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy: A Systematic Review and Meta-analysis of Perioperative, Oncological, and Quality of Life Outcomes Using Randomized Controlled Trials. European Urology 2023, 84: 393-405. PMID: 37169638, DOI: 10.1016/j.eururo.2023.04.004.Peer-Reviewed Original ResearchConceptsRobot-assisted radical cystectomyOpen radical cystectomyRadical cystectomyBlood lossThromboembolic eventsAssociated with better physical functionBladder cancerPositive surgical margin rateAssociated with more blood lossRisk of thromboembolic eventsHealth-related QoLQuality of life outcomesProgression-free survivalSurgical margin rateLymph node yieldRobot-assisted approachShorter operative timeShorter hospital lengthQuality of lifeRandomized controlled trialsSystematic literature searchPhysical functionWeb of ScienceNode yieldOverall survival
2022
Robotic surgery: getting the evidence right
Tan W, Ta A, Kelly J. Robotic surgery: getting the evidence right. The Medical Journal Of Australia 2022, 217: 391-393. PMID: 36183333, PMCID: PMC9828009, DOI: 10.5694/mja2.51726.Peer-Reviewed Original ResearchRetzius-sparing technique independently predicts early recovery of urinary continence after robot-assisted radical prostatectomy
Kadhim H, Ang K, Tan W, Nathan A, Pavan N, Mazzon G, Al-Kadhi O, Di G, Dinneen E, Briggs T, Kelkar A, Rajan P, Nathan S, Kelly J, Sooriakumaran P, Sridhar A. Retzius-sparing technique independently predicts early recovery of urinary continence after robot-assisted radical prostatectomy. Journal Of Robotic Surgery 2022, 16: 1419-1426. PMID: 35192106, DOI: 10.1007/s11701-022-01383-z.Peer-Reviewed Original ResearchConceptsRobot-assisted radical prostatectomySocial urinary continenceBody mass indexNeurovascular bundle sparingRetzius-sparing techniqueRS-RARPUrinary continenceNeurovascular bundleRadical prostatectomyEarly recovery of urinary continenceRecovery of urinary continenceMedian body mass indexMultivariate logistic regression analysisMembranous urethral lengthLocalised prostate cancerHigh-volume institutionsSurgical treatment optionsFollow-up dataLogistic regression analysisConsecutive patientsAssociated with recoveryPad useUrethral lengthMedian ageProstate cancer
2018
Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy
Moschini M, Soria F, Mathieu R, Xylinas E, D'Andrea D, Tan W, Kelly J, Simone G, Tuderti G, Meraney A, Krishna S, Konety B, Zamboni S, Baumeister P, Mattei A, Briganti A, Montorsi F, Galucci M, Rink M, Karakiewicz P, Rouprêt M, Aziz A, Perry M, Rowe E, Koupparis A, Kassouf W, Scherr D, Ploussard G, Boorjian S, Sooriakumaran P, Shariat S, Urologists U. Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy. Urologic Oncology Seminars And Original Investigations 2018, 37: 179.e1-179.e7. PMID: 30446442, DOI: 10.1016/j.urolonc.2018.10.012.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, Transitional CellChemotherapy, AdjuvantCystectomyFemaleFollow-Up StudiesHumansLength of StayLymph Node ExcisionMaleMargins of ExcisionMiddle AgedPostoperative ComplicationsPropensity ScoreRetrospective StudiesRobotic Surgical ProceduresTreatment OutcomeUrinary BladderUrinary Bladder NeoplasmsConceptsSoft tissue surgical marginsRobotic-assisted radical cystectomyOpen radical cystectomyPositive soft tissue surgical marginsRARC groupSoft tissue surgical margin statusRadical cystectomyPropensity-score matchingRARC patientsOpen radical cystectomy groupImpact of surgical techniqueOpen radical cystectomy patientsNon-organ-confinedMultivariate logistic regression analysisOrgan-confined diseaseSurgical margin statusSubgroup of patientsPropensity-score-matched cohortLogistic regression analysisOncologic efficacySurgical marginsPrognostic factorsUrothelial carcinomaMargin statusSurgical techniqueBOXIT—A Randomised Phase III Placebo-controlled Trial Evaluating the Addition of Celecoxib to Standard Treatment of Transitional Cell Carcinoma of the Bladder (CRUK/07/004)
Kelly J, Tan W, Porta N, Mostafid H, Huddart R, Protheroe A, Bogle R, Blazeby J, Palmer A, Cresswell J, Johnson M, Brough R, Madaan S, Andrews S, Cruickshank C, Burnett S, Maynard L, Hall E, Investigators O. BOXIT—A Randomised Phase III Placebo-controlled Trial Evaluating the Addition of Celecoxib to Standard Treatment of Transitional Cell Carcinoma of the Bladder (CRUK/07/004). European Urology 2018, 75: 593-601. PMID: 30279015, DOI: 10.1016/j.eururo.2018.09.020.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravesicalAgedAntibiotics, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsBCG VaccineCarcinoma, Transitional CellCardiovascular DiseasesCelecoxibCyclooxygenase 2 InhibitorsDisease ProgressionDouble-Blind MethodFemaleHumansMaleMiddle AgedMitomycinNeoplasm Recurrence, LocalNeoplasm StagingQuality of LifeRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited KingdomUrinary Bladder NeoplasmsConceptsNon-muscle-invasive bladder cancerHigh-risk non-muscle-invasive bladder cancerRisk of recurrenceIncreased risk of cardiovascular eventsRisk of cardiovascular eventsTime to recurrenceCardiovascular eventsNMIBC patientsBladder cancerStandard treatmentPhase III placebo-controlled trialIntermediate-risk non-muscle-invasive bladder cancerNon-muscle-invasive bladder cancer patientsIncreased riskPatients treated with celecoxibWeekly mitomycin C instillationsMitomycin C instillationAdjuvant intravesical therapyRecurrence-free rateMedian follow-upPlacebo-controlled trialTransitional cell carcinomaHigh-risk patientsCyclo-oxygenase 2 inhibitorsIntravesical therapyIntravesical device-assisted therapies for non-muscle-invasive bladder cancer
Tan W, Kelly J. Intravesical device-assisted therapies for non-muscle-invasive bladder cancer. Nature Reviews Urology 2018, 15: 667-685. PMID: 30254383, DOI: 10.1038/s41585-018-0092-z.Peer-Reviewed Original ResearchConceptsNon-muscle-invasive bladder cancerElectromotive drug administrationDevice-assisted therapiesBladder cancerHyperthermic chemotherapyDevice-assisted treatmentsIntravesical adjuvant treatmentHigh-risk diseaseResults of randomized trialsRisk of recurrenceRisk of progressionAlternative to BCGEffective treatment optionSingle-arm study designBladder cancer diagnosisBCG failureRandomized controlled trialsMaintenance regimensAdjuvant treatmentPatient cohortTreatment optionsRandomized trialsDrug AdministrationControlled trialsClinical guidelines
2017
Outcomes of Intracorporeal Urinary Diversion after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium
Hussein A, May P, Jing Z, Ahmed Y, Wijburg C, Canda A, Dasgupta P, Khan M, Menon M, Peabody J, Hosseini A, Kelly J, Mottrie A, Kaouk J, Hemal A, Wiklund P, Guru K, Collaborators, Wagner A, Saar M, Stockle M, Redorta J, Richstone L, Badani K, Scherr D, Khan H, Gaboardi F, Rha K, Kawa O, Tan W, Schanne F, Polakis V, Weizer A, Maatman T, Pini G, Peak T, Kibel A, Yuh B. Outcomes of Intracorporeal Urinary Diversion after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium. Journal Of Urology 2017, 199: 1302-1311. PMID: 29275112, DOI: 10.1016/j.juro.2017.12.045.Peer-Reviewed Original ResearchMeSH KeywordsAgedCystectomyFemaleHumansInternational CooperationMaleMiddle AgedOperative TimeOutcome and Process Assessment, Health CarePatient ReadmissionPostoperative ComplicationsProspective StudiesRetrospective StudiesRisk FactorsRobotic Surgical ProceduresTreatment OutcomeUrinary BladderUrinary Bladder NeoplasmsUrinary DiversionConceptsRobot-assisted radical cystectomyIntracorporeal urinary diversionExtracorporeal urinary diversionShorter operative timeRadical cystectomyHigh grade complicationsUrinary diversionOperative timeGrade complicationsInternational Robotic Cystectomy Consortium databaseInternational Robotic Cystectomy ConsortiumCompare perioperative outcomesLess blood lossMultivariate logistic regression modelPostoperative predictorsBlood lossPerioperative outcomesBlood transfusionCystectomy volumeCystectomyLogistic regression modelsComplicationsConsortium databaseMulti-institutionalPatientsIntracorporeal robot‐assisted radical cystectomy, together with an enhanced recovery programme, improves postoperative outcomes by aggregating marginal gains
Tan W, Tan M, Lamb B, Sridhar A, Mohammed A, Baker H, Nathan S, Briggs T, Tan M, Kelly J. Intracorporeal robot‐assisted radical cystectomy, together with an enhanced recovery programme, improves postoperative outcomes by aggregating marginal gains. BJU International 2017, 121: 632-639. PMID: 29124853, DOI: 10.1111/bju.14073.Peer-Reviewed Original ResearchConceptsLength of hospital stayOpen radical cystectomyRobot-assisted radical cystectomyPeri-operative outcomesRadical cystectomyERAS programmeERAS groupERAS pathwayReadmission ratesOpen radical cystectomy groupAmerican Society of Anesthesiologists scoreIntracorporeal robot-assisted radical cystectomyPeri-operative anaemiaLymph node yieldRadical cystectomy casesClavien-Dindo systemScore-matched cohort of patientsCohort of patientsLevel 1 evidenceImproving postoperative outcomesIntracorporeal urinary diversionBody mass indexScore-matched cohortGastrointestinal-related complicationsPrimary outcome measure
2016
Robotic Assisted Radical Cystectomy with Extracorporeal Urinary Diversion Does Not Show a Benefit over Open Radical Cystectomy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Tan W, Khetrapal P, Tan W, Rodney S, Chau M, Kelly J. Robotic Assisted Radical Cystectomy with Extracorporeal Urinary Diversion Does Not Show a Benefit over Open Radical Cystectomy: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. PLOS ONE 2016, 11: e0166221. PMID: 27820855, PMCID: PMC5098822, DOI: 10.1371/journal.pone.0166221.Peer-Reviewed Original ResearchConceptsRobot-assisted radical cystectomyOpen radical cystectomyMeta-analysis of randomised controlled trialsExtracorporeal urinary diversionRandomised controlled trialsRadical cystectomyUrinary diversionPerioperative morbidityBladder cancerLack of Level I evidenceRobot-assisted radical cystectomy groupsPositive lymph node statusOutcomes of robot-assisted radical cystectomySystematic reviewControlled trialsOpen radical cystectomy patientsEfficacy of robot-assisted radical cystectomyInclusion criteriaPositive surgical marginsLymph node statusLymph node yieldMeta-analysisLevel I evidenceIntracorporeal urinary diversionWell-designed trialsPort-Site Metastases After Robotic Radical Cystectomy: A Systematic Review and Management Options
Khetrapal P, Tan W, Lamb B, Nathan S, Briggs T, Shankar A, Ramachandran N, Freeman A, Mitra A, Kelly J. Port-Site Metastases After Robotic Radical Cystectomy: A Systematic Review and Management Options. Clinical Genitourinary Cancer 2016, 15: 440-444. PMID: 28209455, DOI: 10.1016/j.clgc.2016.06.012.Peer-Reviewed Original ResearchConceptsRobot-assisted radical cystectomyPort-site metastasisRadical cystectomyCase of port-site metastasisLymph node-positive diseaseMuscle-invasive bladder cancerIntracorporeal robot-assisted radical cystectomySystematic reviewNode-positive diseaseSystematic review of MEDLINERobotic radical cystectomyIdentified 4 casesTreatment of chemotherapyReview of MEDLINEDisease-free statusSalvage chemotherapyPrimary tumorSurgical excisionMultimodal treatmentPublished studiesAggressive treatmentBladder cancerTreatment optionsEmbase databasesPatient factorsBenefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: A prospective cohort study
Lamb B, Tan W, Eneje P, Bruce D, Jones A, Ahmad I, Sridhar A, Baker H, Briggs T, Hines J, Nathan S, Martin D, Stephens R, Kelly J. Benefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: A prospective cohort study. Urologic Oncology Seminars And Original Investigations 2016, 34: 417.e17-417.e23. PMID: 27197920, DOI: 10.1016/j.urolonc.2016.04.006.Peer-Reviewed Original ResearchConceptsCardiopulmonary exercise testing measurementsCardiopulmonary exercise testingHospital length of stayLength of stayProspective cohort studyRadical cystectomyCardiorespiratory fitnessAnaerobic thresholdRobotic cystectomyIntracorporeal diversionCohort studyIncreased hospital LOSInstitution prospective cohort studyHigh-grade bladder cancerPreoperative cardiopulmonary exercise testingRobotic radical cystectomyLow cardiorespiratory fitnessPoor cardiorespiratory fitnessReduced cardiorespiratory fitnessBody mass indexAbsence of control groupsOpen surgeryPatient demographicsBladder cancerCystectomyAnalysis of open and intracorporeal robotic assisted radical cystectomy shows no significant difference in recurrence patterns and oncological outcomes
Tan W, Sridhar A, Ellis G, Lamb B, Goldstraw M, Nathan S, Hines J, Cathcart P, Briggs T, Kelly J. Analysis of open and intracorporeal robotic assisted radical cystectomy shows no significant difference in recurrence patterns and oncological outcomes. Urologic Oncology Seminars And Original Investigations 2016, 34: 257.e1-257.e9. PMID: 26968561, DOI: 10.1016/j.urolonc.2016.02.010.Peer-Reviewed Original ResearchConceptsRecurrence free survivalCancer-specific survivalOpen radical cystectomyORC cohortOverall survivalRadical cystectomySpecific survivalNo significant differenceOncological outcomesSignificant differenceOpen radical cystectomy casesPositive surgical margin rateIntracorporeal robot-assisted radical cystectomyRobotic-assisted radical cystectomyRobot-assisted radical cystectomyEarly oncologic outcomesPreoperative chemotherapy useSurgical margin rateLymph node yieldMedian follow-upKaplan-Meir analysisCox regression analysisIntracorporeal urinary diversionRecurrence patternsPT0 status
2015
Robot‐assisted intracorporeal pyramid neobladder
Tan W, Sridhar A, Goldstraw M, Zacharakis E, Nathan S, Hines J, Cathcart P, Briggs T, Kelly J. Robot‐assisted intracorporeal pyramid neobladder. BJU International 2015, 116: 771-779. PMID: 26033321, DOI: 10.1111/bju.13189.Peer-Reviewed Original ResearchConceptsRobot-assisted radical cystectomyMuscle-invasive bladder cancerUrinary tract infectionPostoperative complicationsFunctional outcomesMedian estimated blood lossNight time continenceBilateral pelvic lymphadenectomyEstimated blood lossMedian hospital stayRecurrence-free survivalUpper tract imagingMedian follow-upLate postoperative complicationsEarly postoperative complicationsPort-site herniaUretero-ileal strictureVitamin B12 deficiencyBlocked stentsNeobladder stonePelvic lymphadenectomyOncological outcomesRadical cystectomyOverall survivalBlood loss
2014
Management of Node-Positive Bladder Cancer After Neoadjuvant Chemotherapy and Radical Cystectomy: A Survey of Current UK Practice
Tan W, Lamb B, Payne H, Hughes S, Green J, Lane T, Adshead J, Boustead G, Vasdev N. Management of Node-Positive Bladder Cancer After Neoadjuvant Chemotherapy and Radical Cystectomy: A Survey of Current UK Practice. Clinical Genitourinary Cancer 2014, 13: e153-e158. PMID: 25510376, DOI: 10.1016/j.clgc.2014.11.006.Peer-Reviewed Original ResearchConceptsNeoadjuvant chemotherapy regimenNeoadjuvant chemotherapyPositive lymph nodesRadical cystectomyAdjuvant chemotherapyTreatment of patientsBladder cancerNodal diseaseLymph nodesIndication of adjuvant chemotherapyNode-positive bladder cancerPresence of disease progressionResponse to NACCancer CenterMuscle-invasive bladder cancerCycles of gemcitabineAdvanced bladder cancerPatient performance statusUro-oncologistsChemotherapy regimenPerformance statusLack of published evidenceDisease progressionChemotherapyPatients
2013
Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study
Tan W, Low W, Ng C, Tan W, Tong S, Ho C, Khoo E, Lee G, Lee B, Lee V, Tan H. Efficacy and safety of long‐acting intramuscular testosterone undecanoate in aging men: a randomised controlled study. BJU International 2013, 111: 1130-1140. PMID: 23651425, DOI: 10.1111/bju.12037.Peer-Reviewed Original ResearchConceptsProstate-specific antigenTestosterone undecanoateTestosterone deficiencyTreatment armsAdverse eventsSex hormone-binding globulinIntramuscular testosterone undecanoateCommon adverse eventsIncreased serum testosteroneHormone-binding globulinLiver function testsCessation of treatmentFasting blood glucosePhysical examination resultsRandomised controlled studySite of injectionTU injectionsPlacebo armSerum TTSerum testosteroneSpecific antigenAdverse reactionsLipid profileFunction testsControlled studies