2019
Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex
Shu P, Wu C, Ruan X, Liu W, Hou L, Fu H, Wang M, Liu C, Zeng Y, Chen P, Yin B, Yuan J, Qiang B, Peng X, Zhong W. Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex. Developmental Cell 2019, 49: 764-785.e4. PMID: 31080058, DOI: 10.1016/j.devcel.2019.04.017.Peer-Reviewed Original Research
2008
Going Nuclear Is Again a Winning (Wnt) Strategy
Zhong W. Going Nuclear Is Again a Winning (Wnt) Strategy. Developmental Cell 2008, 15: 635-636. PMID: 19000826, DOI: 10.1016/j.devcel.2008.10.012.Peer-Reviewed Original ResearchTiming cell-fate determination during asymmetric cell divisions
Zhong W. Timing cell-fate determination during asymmetric cell divisions. Current Opinion In Neurobiology 2008, 18: 472-478. PMID: 18983918, PMCID: PMC2609754, DOI: 10.1016/j.conb.2008.10.005.Peer-Reviewed Original ResearchConceptsAsymmetric cell divisionCell divisionCell cycle progressionFate determinantsCell fate determinantsCell fate determinationCell fateDaughter cellsCellular organellesMolecular mechanismsCell cycleGolgi apparatusIntracellular signalingSubcellular distributionDifferent fatesCell typesNovel mechanismCell proliferationMolecular compositionMultiple roundsRecent findingsDivisionFateInvertebratesCentrosomesNeurogenesis and asymmetric cell division
Zhong W, Chia W. Neurogenesis and asymmetric cell division. Current Opinion In Neurobiology 2008, 18: 4-11. PMID: 18513950, DOI: 10.1016/j.conb.2008.05.002.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsAsymmetric divisionMammalian neural progenitor cellsAsymmetric cell divisionProgenitor cellsCellular diversityGlial progenyCell divisionCell biologyNeuronal lineageNeural progenitorsCentral nervous systemDivisionNeurogenesisDrosophilaVertebratesCellsLineagesNervous systemBiologyProgenyProgenitorsDiversityNeuroblastsSimilarity
2007
The Mammalian Golgi Regulates Numb Signaling in Asymmetric Cell Division by Releasing ACBD3 during Mitosis
Zhou Y, Atkins JB, Rompani SB, Bancescu DL, Petersen PH, Tang H, Zou K, Stewart SB, Zhong W. The Mammalian Golgi Regulates Numb Signaling in Asymmetric Cell Division by Releasing ACBD3 during Mitosis. Cell 2007, 129: 163-178. PMID: 17418793, DOI: 10.1016/j.cell.2007.02.037.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAnimals, Genetically ModifiedCell DivisionCell LineageCytosolDrosophilaEmbryo, MammalianEmbryo, NonmammalianEmbryonic DevelopmentGolgi ApparatusMembrane ProteinsMiceMitosisNerve Tissue ProteinsNeuronsPhenotypeProtein Structure, TertiaryReceptors, GABA-ASignal TransductionStem CellsConceptsCell fate specificationNumb proteinDaughter cellsGolgi fragmentationCell cycleMammalian neural progenitor cellsAsymmetric cell divisionProgenitor cell cycleProgenitor cellsCell cycle progressionNeural progenitor cellsMammalian GolgiCell fateCell divisionNeuronal fateACBD3Golgi apparatusSubcellular distributionNeuronal differentiationPhenotypic similarityNumbMitosisNeuron productionProteinCells
2005
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon
Backman M, Machon O, Mygland L, van den Bout CJ, Zhong W, Taketo MM, Krauss S. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Developmental Biology 2005, 279: 155-168. PMID: 15708565, DOI: 10.1016/j.ydbio.2004.12.010.Peer-Reviewed Original Research
2004
Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis
Petersen PH, Zou K, Krauss S, Zhong W. Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nature Neuroscience 2004, 7: 803-811. PMID: 15273690, DOI: 10.1038/nn1289.Peer-Reviewed Original ResearchConceptsMouse NumbProgenitor cellsEarly neurogenesisAsymmetric cell divisionProgenitor cell maintenanceLoss of NumbNeural progenitor cellsProgenitor cell depletionDrosophila melanogasterCell fateCell divisionNeuronal fateNumblNumbCortical neurogenesisStem cellsGeneral mechanismDorsal forebrainNeurogenesisCellsNervous systemFateSpecific malformationsDifferent neuronsMelanogasterNestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons
Beech RD, Cleary MA, Treloar HB, Eisch AJ, Harrist AV, Zhong W, Greer CA, Duman RS, Picciotto MR. Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons. The Journal Of Comparative Neurology 2004, 475: 128-141. PMID: 15176089, DOI: 10.1002/cne.20179.Peer-Reviewed Original ResearchConceptsPG neuronsSubventricular zoneGranule cellsOlfactory bulbMajor neurogenic regionsAdult-generated neuronsSVZ precursor cellsTetracycline transactivatorRostral migratory streamOlfactory bulb interneuronsTransgene expressionPeriglomerular neuronsPeriglomerular cellsNestin promoterTyrosine hydroxylaseAdult brainInterneuronal populationsBulb interneuronsNeurogenic regionsMigratory streamNeuronal precursorsNeuronsUnique subsetPromoter/enhancerPrecursor cells
2003
Diversifying Neural Cells through Order of Birth and Asymmetry of Division
Zhong W. Diversifying Neural Cells through Order of Birth and Asymmetry of Division. Neuron 2003, 37: 11-14. PMID: 12526768, DOI: 10.1016/s0896-6273(02)01178-9.Peer-Reviewed Original ResearchConceptsAsymmetry of divisionCell fate diversificationCell fate determinationAsymmetric cell divisionMature nervous systemFate diversificationDrosophila genesFate determinationCell divisionCell typesProgenitor cellsNeural cellsDevelopmental neurobiologyNervous systemCommon setCellsDivisionGenesDiversityDiversificationKey questions
2002
Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.
Shen Q, Zhong W, Jan YN, Temple S. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 2002, 129: 4843-53. PMID: 12361975, DOI: 10.1242/dev.129.20.4843.Peer-Reviewed Original ResearchConceptsAsymmetric cell divisionCell divisionMouse cortical developmentCell fateStem cellsProgenitor cellsDiverse cell fatesNeural cell fateMouse cortical neurogenesisNext cell divisionEmbryonic mouse cortexDrosophila neurogenesisProgenitor marker nestinAsymmetric segregationLineage treesNumb proteinCortical stem cellsMouse homologueNotch activityWild typeNumbNeuronal differentiationNeuronal cellsCortical neurogenesisCortical development
2000
Mouse numb is an essential gene involved in cortical neurogenesis
Zhong W, Jiang M, Schonemann M, Meneses J, Pedersen R, Jan L, Jan Y. Mouse numb is an essential gene involved in cortical neurogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6844-6849. PMID: 10841580, PMCID: PMC18761, DOI: 10.1073/pnas.97.12.6844.Peer-Reviewed Original ResearchConceptsEssential genesDaughter cellsProgenitor cellsCranial neural tube closureFunction mutant allelesApical daughter cellMembrane-associated proteinsProgenitor cell fateCortical neurogenesisNeural tube closureEmbryonic day 11.5Neural progenitor cellsCortical progenitor cellsNumb functionsCell fateApical cell membraneNumb geneSevere defectsTube closureMutant allelesNeural developmentDay 11.5Cell membraneGenesMammalian neocortex
1999
DLX‐1, DLX‐2, and DLX‐5 expression define distinct stages of basal forebrain differentiation
Eisenstat D, Liu J, Mione M, Zhong W, Yu G, Anderson S, Ghattas I, Puelles L, Rubenstein J. DLX‐1, DLX‐2, and DLX‐5 expression define distinct stages of basal forebrain differentiation. The Journal Of Comparative Neurology 1999, 414: 217-237. PMID: 10516593, DOI: 10.1002/(sici)1096-9861(19991115)414:2<217::aid-cne6>3.0.co;2-i.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsAntibody SpecificityBasal GangliaCell DifferentiationCell NucleusCerebral VentriclesCytoplasmGene Expression Regulation, DevelopmentalHomeodomain ProteinsIn Situ HybridizationIsomerismMiceMitosisMutagenesisNeuronsProsencephalonRecombinant ProteinsRNA, MessengerS PhaseTranscription FactorsConceptsDlx-2Dlx-1Dlx-5Dlx genesDlx-5 expressionEmbryonic day 10.5Ventricular zoneDlx proteinsDlx familyM phase cellsCraniofacial morphogenesisHomeobox genesSingle mutantsDaughter cellsDay 10.5GenesForebrain differentiationProteinSame cellsMouse forebrainMild phenotypeCellsDifferentiationExpressionDistinct stages
1997
Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis
Zhong W, Jiang M, Weinmaster G, Jan L, Jan Y. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 1997, 124: 1887-1897. PMID: 9169836, DOI: 10.1242/dev.124.10.1887.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceCerebral CortexCloning, MolecularCytoplasmDrosophilaDrosophila ProteinsGene Expression Regulation, DevelopmentalGenesIntracellular Signaling Peptides and ProteinsJuvenile HormonesMembrane ProteinsMiceModels, NeurologicalMolecular Sequence DataMorphogenesisMutationNerve Tissue ProteinsNervous SystemNeuronsOrgan SpecificityReceptor, Notch1Receptors, Cell SurfaceRecombinant Fusion ProteinsRNA, MessengerSequence Homology, Amino AcidStem CellsTranscription FactorsConceptsDaughter cellsNeural precursorsMammalian cortical neurogenesisAsymmetric cell divisionSignificant sequence similarityMouse cortical neurogenesisCortical neurogenesisEmbryonic nervous systemFunction mutant embryosCell-cell interactionsCell-intrinsic mechanismsMammalian NumbMouse NumbNumb lossProgenitor cell proliferationDrosophila neurogenesisMammalian genesMutant embryosCell-extrinsic mechanismsSequence similarityCell divisionDifferential segregationNumblikePostmitotic neuronsNumb
1996
Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
Zhong W, Feder J, Jiang M, Jan L, Jan Y. Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis. Neuron 1996, 17: 43-53. PMID: 8755477, DOI: 10.1016/s0896-6273(00)80279-2.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DivisionCell MembraneCerebral CortexDrosophilaDrosophila ProteinsEmbryo, MammalianEmbryo, NonmammalianEmbryonic and Fetal DevelopmentJuvenile HormonesMembrane ProteinsMiceMolecular Sequence DataMutationNeuronsRatsReceptors, Cell SurfaceReceptors, NotchSequence Homology, Amino AcidTissue DistributionConceptsMouse cortical neurogenesisDaughter cellsAsymmetric cell divisionCortical neurogenesisCell-cell interactionsDrosophila neurogenesisMammalian homologMutant phenotypeMouse Notch1Drosophila embryosDistinct fatesDrosophila NumbAsymmetric divisionAsymmetric localizationCell divisionDifferential segregationMolecular mechanismsNeural progenitorsNumbNeural precursorsApical membraneHomologNeurogenesisInvertebratesVertebrates