2004
Major Molecular Differences between Mammalian Sexes Are Involved in Drug Metabolism and Renal Function
Rinn JL, Rozowsky JS, Laurenzi IJ, Petersen PH, Zou K, Zhong W, Gerstein M, Snyder M. Major Molecular Differences between Mammalian Sexes Are Involved in Drug Metabolism and Renal Function. Developmental Cell 2004, 6: 791-800. PMID: 15177028, DOI: 10.1016/j.devcel.2004.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNAFemaleGene Expression ProfilingGene Expression RegulationGenitaliaHumansHypothalamusKidneyLiverMaleMetabolic Clearance RateMiceOligonucleotide Array Sequence AnalysisOrgan SpecificityOvaryPharmaceutical PreparationsReceptors, Cell SurfaceSerpinsSex CharacteristicsTestisTranscortinConceptsMolecular differencesGene expressionExtensive differential gene expressionReproductive tissuesDifferential gene expressionGene expression differencesCellular rolesMammalian sexMouse geneMajor molecular differencesExpression differencesAdult tissuesOsmotic regulationExpression patternsFemale hypothalamusMolecular levelPhysiological differencesGenesDifferent hormonal environmentsRenal functionHormonal environmentExpressionSteroid metabolismMetabolismDrug metabolism
1994
Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression.
Zhong W, Mirkovitch J, Darnell J. Tissue-specific regulation of mouse hepatocyte nuclear factor 4 expression. Molecular And Cellular Biology 1994, 14: 7276-7284. PMID: 7523862, PMCID: PMC359262, DOI: 10.1128/mcb.14.11.7276.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBinding SitesDeoxyribonuclease IDNA ProbesDNA-Binding ProteinsGene Expression RegulationHepatocyte Nuclear Factor 4KidneyLiverLiver Neoplasms, ExperimentalMiceMice, TransgenicMolecular Sequence DataPhosphoproteinsPromoter Regions, GeneticRNATissue DistributionTranscription FactorsTransfectionTumor Cells, CulturedConceptsTransient transfection assaysLiver-enriched transcription factorsHNF-4HNF-4 geneLiver-specific expressionTranscription factorsPresence of DNase I-hypersensitive sitesHNF-1 binding siteDNase I hypersensitive sitesHepatocyte nuclear factor 4Distal enhancer elementsDNase hypersensitive sitesHepatoma-specific expressionSteroid hormone receptor superfamilyHNF-4 expressionTissue-specific expressionHNF-1 alphaHormone receptor superfamilyExpression of HNF-4RNA startDNA elementsEnhancer elementsHNF-1Promoter regionReporter constructs
1993
The expression pattern of a Drosophila homolog to the mouse transcription factor HNF‐4 suggests a determinative role in gut formation.
Zhong W, Sladek F, Darnell J. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF‐4 suggests a determinative role in gut formation. The EMBO Journal 1993, 12: 537-544. PMID: 8440243, PMCID: PMC413236, DOI: 10.1002/j.1460-2075.1993.tb05685.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsChromosome DeletionChromosome MappingDNA-Binding ProteinsDrosophilaGene ExpressionHepatocyte Nuclear Factor 4In Situ HybridizationIntestinal MucosaIntestinesKidneyLiverMiceMolecular Sequence DataPhenotypePhosphoproteinsRNA, MessengerSequence Homology, Amino AcidTranscription FactorsConceptsDNA-binding domainDrosophila genesGut formationHNF-4Binding domainIdentical DNA binding domainsZinc finger DNA-binding domainHepatocyte nuclear factor 3Transcription factor HNF-4Amino acidsGroup of genesLiver-specific gene expressionDrosophila homologDrosophila embryoDrosophila mutantsMouse genesHNF-3Cross-hybridizationLate embryogenesisChromosomal deletionsDrosophilaFat bodyGene expressionExpression patternsGenes
1990
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
Sladek F, Zhong W, Lai E, Darnell J. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Development 1990, 4: 2353-2365. PMID: 2279702, DOI: 10.1101/gad.4.12b.2353.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBinding SitesCell NucleusCloning, MolecularDNA-Binding ProteinsGene ExpressionHepatocyte Nuclear Factor 4LiverMacromolecular SubstancesMaleMolecular Sequence DataMultigene FamilyOligonucleotide ProbesPhosphoproteinsRatsRats, Inbred StrainsReceptors, SteroidRecombinant ProteinsSequence Homology, Nucleic AcidTranscription FactorsTranscription, GeneticConceptsSteroid hormone receptor superfamilyHNF-4 proteinHNF-4Hormone receptor superfamilyReceptor superfamilyTranscription factor HNF-4Regulation of transcriptionAmino acid sequencePyruvate kinase geneLigand-dependent transcription factorSequence-specific fashionDNA binding activityPolymerase chain reactionHNF-4 mRNANorthern blot analysisUnusual amino acidsLF-A1CDNA clonesActivate transcriptionBinding to sitesZinc fingerCotransfection assaysDNA bindingSynthetic oligonucleotidesTranscription factors