2019
Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex
Shu P, Wu C, Ruan X, Liu W, Hou L, Fu H, Wang M, Liu C, Zeng Y, Chen P, Yin B, Yuan J, Qiang B, Peng X, Zhong W. Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex. Developmental Cell 2019, 49: 764-785.e4. PMID: 31080058, DOI: 10.1016/j.devcel.2019.04.017.Peer-Reviewed Original Research
2013
Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation
Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M. Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development 2013, 141: 281-295. PMID: 24335256, PMCID: PMC3879810, DOI: 10.1242/dev.093690.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell LineageCell ProliferationEmbryonic Stem CellsFemaleHeartHeart Defects, CongenitalIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceMice, KnockoutMice, TransgenicMorphogenesisMyocardiumMyocytes, CardiacNerve Tissue ProteinsPregnancyReceptor, Notch1Signal TransductionConceptsNumb family proteinsCardiac progenitor differentiationCardiac progenitor cell differentiationSecond heart fieldProgenitor differentiationCardiac morphogenesisEndocytosis-dependent mannerProgenitor cell differentiationFamily proteinsCell differentiationOFT alignmentMultiple progenitor cell typesCell fate determinantsLate cardiac developmentEarly embryonic lethalityMRNA deep sequencingProgenitor cell typesSuppression of Notch1Fate determinantsNotch1 intracellular domainEmbryonic lethalEmbryonic lethalityReporter linesDifferentiation defectsHeart field
2011
Golgi during Development
Zhong W. Golgi during Development. Cold Spring Harbor Perspectives In Biology 2011, 3: a005363. PMID: 21768608, PMCID: PMC3181030, DOI: 10.1101/cshperspect.a005363.Peer-Reviewed Original ResearchConceptsPlasma membrane componentsSecretory traffickingSecretory pathwayProcessing proteinsCellular differentiationDevelopmental pathwaysProtein cleavageMembrane componentsGolgiAspects of developmentSpatial organizationMajor compartmentsPathwayFinal destinationInvertebratesVertebratesMorphogenesisOrganellesTraffickingGlycosylationProteinSpecific effectsDifferentiationCompartmentsCleavage
2008
Going Nuclear Is Again a Winning (Wnt) Strategy
Zhong W. Going Nuclear Is Again a Winning (Wnt) Strategy. Developmental Cell 2008, 15: 635-636. PMID: 19000826, DOI: 10.1016/j.devcel.2008.10.012.Peer-Reviewed Original ResearchTiming cell-fate determination during asymmetric cell divisions
Zhong W. Timing cell-fate determination during asymmetric cell divisions. Current Opinion In Neurobiology 2008, 18: 472-478. PMID: 18983918, PMCID: PMC2609754, DOI: 10.1016/j.conb.2008.10.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell DivisionCell LineageGolgi ApparatusHumansModels, BiologicalNeuronsSignal TransductionStem CellsConceptsAsymmetric cell divisionCell divisionCell cycle progressionFate determinantsCell fate determinantsCell fate determinationCell fateDaughter cellsCellular organellesMolecular mechanismsCell cycleGolgi apparatusIntracellular signalingSubcellular distributionDifferent fatesCell typesNovel mechanismCell proliferationMolecular compositionMultiple roundsRecent findingsDivisionFateInvertebratesCentrosomesNeurogenesis and asymmetric cell division
Zhong W, Chia W. Neurogenesis and asymmetric cell division. Current Opinion In Neurobiology 2008, 18: 4-11. PMID: 18513950, DOI: 10.1016/j.conb.2008.05.002.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsAsymmetric divisionMammalian neural progenitor cellsAsymmetric cell divisionProgenitor cellsCellular diversityGlial progenyCell divisionCell biologyNeuronal lineageNeural progenitorsCentral nervous systemDivisionNeurogenesisDrosophilaVertebratesCellsLineagesNervous systemBiologyProgenyProgenitorsDiversityNeuroblastsSimilarity
2006
The Enigma of the Numb-Notch Relationship during Mammalian Embryogenesis
Petersen PH, Tang H, Zou K, Zhong W. The Enigma of the Numb-Notch Relationship during Mammalian Embryogenesis. Developmental Neuroscience 2006, 28: 156-168. PMID: 16508312, DOI: 10.1159/000090761.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell DifferentiationCell DivisionCell LineageDrosophila melanogasterEmbryo, MammalianEmbryo, NonmammalianEmbryonic DevelopmentGene Expression Regulation, DevelopmentalGenes, HomeoboxMammalsMembrane ProteinsMesodermMiceMice, Mutant StrainsMutationNerve Tissue ProteinsProtein IsoformsReceptors, NotchSomitesStem CellsConceptsAsymmetric cell divisionAntagonistic rolesCell divisionCell fate specificationStem cell maintenanceDefective Notch signalingEmbryonic nervous systemStem/progenitor cellsMammalian embryogenesisNeural stem/progenitor cellsFate specificationCell fateNumb proteinCell maintenanceNumb isoformsMammalian neurogenesisMolecular basisNotch signalingDifferent fatesNumbDifferential regulationStem cellsProgenitor cellsEmbryogenesisPremature depletion
2005
The Notch Regulator Numb Links the Notch and TCR Signaling Pathways
Anderson AC, Kitchens EA, Chan SW, St. Hill C, Jan YN, Zhong W, Robey EA. The Notch Regulator Numb Links the Notch and TCR Signaling Pathways. The Journal Of Immunology 2005, 174: 890-897. PMID: 15634911, DOI: 10.4049/jimmunol.174.2.890.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen-Presenting CellsCell DifferentiationCells, CulturedGene DeletionIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, TransgenicNerve Tissue ProteinsReceptor, Notch1Receptors, Antigen, T-CellReceptors, Cell SurfaceSignal TransductionT-LymphocytesThymus GlandTranscription FactorsConceptsT cell developmentTCR signaling pathwaysCell developmentSignaling pathwaysAbsence of NumbT cell-APC interactionsInhibitor of NotchProtein NumbImportant adapterRelated proteinsNumbAPC contactMature T cellsTCR signalsCell membraneT cell activationPhysical interactionPathwayCell activationNotchImportant roleNumblikeProteinMutationsCoclusters
2003
Diversifying Neural Cells through Order of Birth and Asymmetry of Division
Zhong W. Diversifying Neural Cells through Order of Birth and Asymmetry of Division. Neuron 2003, 37: 11-14. PMID: 12526768, DOI: 10.1016/s0896-6273(02)01178-9.Peer-Reviewed Original ResearchConceptsAsymmetry of divisionCell fate diversificationCell fate determinationAsymmetric cell divisionMature nervous systemFate diversificationDrosophila genesFate determinationCell divisionCell typesProgenitor cellsNeural cellsDevelopmental neurobiologyNervous systemCommon setCellsDivisionGenesDiversityDiversificationKey questions
2002
Progenitor cell maintenance requires numb and numblike during mouse neurogenesis
Petersen PH, Zou K, Hwang JK, Jan YN, Zhong W. Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature 2002, 419: 929-934. PMID: 12410312, DOI: 10.1038/nature01124.Peer-Reviewed Original ResearchConceptsMouse NumbNeural progenitor cellsMolecular mechanismsProgenitor cellsProgenitor cell maintenanceMammalian nervous systemOnset of neurogenesisConserved homologuesMutant embryosCourse of neurogenesisCell maintenanceMouse neurogenesisNeuronal fateNumbDividing cellsNeural cellsEarly neuronsNervous systemCritical roleProgenitorsCellsNeurogenesisDrosophilaTemporal patternsEmbryogenesis
1999
DLX‐1, DLX‐2, and DLX‐5 expression define distinct stages of basal forebrain differentiation
Eisenstat D, Liu J, Mione M, Zhong W, Yu G, Anderson S, Ghattas I, Puelles L, Rubenstein J. DLX‐1, DLX‐2, and DLX‐5 expression define distinct stages of basal forebrain differentiation. The Journal Of Comparative Neurology 1999, 414: 217-237. PMID: 10516593, DOI: 10.1002/(sici)1096-9861(19991115)414:2<217::aid-cne6>3.0.co;2-i.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsAntibody SpecificityBasal GangliaCell DifferentiationCell NucleusCerebral VentriclesCytoplasmGene Expression Regulation, DevelopmentalHomeodomain ProteinsIn Situ HybridizationIsomerismMiceMitosisMutagenesisNeuronsProsencephalonRecombinant ProteinsRNA, MessengerS PhaseTranscription FactorsConceptsDlx-2Dlx-1Dlx-5Dlx genesDlx-5 expressionEmbryonic day 10.5Ventricular zoneDlx proteinsDlx familyM phase cellsCraniofacial morphogenesisHomeobox genesSingle mutantsDaughter cellsDay 10.5GenesForebrain differentiationProteinSame cellsMouse forebrainMild phenotypeCellsDifferentiationExpressionDistinct stages