Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.
Sladek F, Zhong W, Lai E, Darnell J. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Development 1990, 4: 2353-2365. PMID: 2279702, DOI: 10.1101/gad.4.12b.2353.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBinding SitesCell NucleusCloning, MolecularDNA-Binding ProteinsGene ExpressionHepatocyte Nuclear Factor 4LiverMacromolecular SubstancesMaleMolecular Sequence DataMultigene FamilyOligonucleotide ProbesPhosphoproteinsRatsRats, Inbred StrainsReceptors, SteroidRecombinant ProteinsSequence Homology, Nucleic AcidTranscription FactorsTranscription, GeneticConceptsSteroid hormone receptor superfamilyHNF-4 proteinHNF-4Hormone receptor superfamilyReceptor superfamilyTranscription factor HNF-4Regulation of transcriptionAmino acid sequencePyruvate kinase geneLigand-dependent transcription factorSequence-specific fashionDNA binding activityPolymerase chain reactionHNF-4 mRNANorthern blot analysisUnusual amino acidsLF-A1CDNA clonesActivate transcriptionBinding to sitesZinc fingerCotransfection assaysDNA bindingSynthetic oligonucleotidesTranscription factors