2013
Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation
Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M. Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development 2013, 141: 281-295. PMID: 24335256, PMCID: PMC3879810, DOI: 10.1242/dev.093690.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell LineageCell ProliferationEmbryonic Stem CellsFemaleHeartHeart Defects, CongenitalIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiceMice, KnockoutMice, TransgenicMorphogenesisMyocardiumMyocytes, CardiacNerve Tissue ProteinsPregnancyReceptor, Notch1Signal TransductionConceptsNumb family proteinsCardiac progenitor differentiationCardiac progenitor cell differentiationSecond heart fieldProgenitor differentiationCardiac morphogenesisEndocytosis-dependent mannerProgenitor cell differentiationFamily proteinsCell differentiationOFT alignmentMultiple progenitor cell typesCell fate determinantsLate cardiac developmentEarly embryonic lethalityMRNA deep sequencingProgenitor cell typesSuppression of Notch1Fate determinantsNotch1 intracellular domainEmbryonic lethalEmbryonic lethalityReporter linesDifferentiation defectsHeart field
2000
Mouse numb is an essential gene involved in cortical neurogenesis
Zhong W, Jiang M, Schonemann M, Meneses J, Pedersen R, Jan L, Jan Y. Mouse numb is an essential gene involved in cortical neurogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6844-6849. PMID: 10841580, PMCID: PMC18761, DOI: 10.1073/pnas.97.12.6844.Peer-Reviewed Original ResearchConceptsEssential genesDaughter cellsProgenitor cellsCranial neural tube closureFunction mutant allelesApical daughter cellMembrane-associated proteinsProgenitor cell fateCortical neurogenesisNeural tube closureEmbryonic day 11.5Neural progenitor cellsCortical progenitor cellsNumb functionsCell fateApical cell membraneNumb geneSevere defectsTube closureMutant allelesNeural developmentDay 11.5Cell membraneGenesMammalian neocortex