2004
Major Molecular Differences between Mammalian Sexes Are Involved in Drug Metabolism and Renal Function
Rinn JL, Rozowsky JS, Laurenzi IJ, Petersen PH, Zou K, Zhong W, Gerstein M, Snyder M. Major Molecular Differences between Mammalian Sexes Are Involved in Drug Metabolism and Renal Function. Developmental Cell 2004, 6: 791-800. PMID: 15177028, DOI: 10.1016/j.devcel.2004.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDNAFemaleGene Expression ProfilingGene Expression RegulationGenitaliaHumansHypothalamusKidneyLiverMaleMetabolic Clearance RateMiceOligonucleotide Array Sequence AnalysisOrgan SpecificityOvaryPharmaceutical PreparationsReceptors, Cell SurfaceSerpinsSex CharacteristicsTestisTranscortinConceptsMolecular differencesGene expressionExtensive differential gene expressionReproductive tissuesDifferential gene expressionGene expression differencesCellular rolesMammalian sexMouse geneMajor molecular differencesExpression differencesAdult tissuesOsmotic regulationExpression patternsFemale hypothalamusMolecular levelPhysiological differencesGenesDifferent hormonal environmentsRenal functionHormonal environmentExpressionSteroid metabolismMetabolismDrug metabolism
1993
The expression pattern of a Drosophila homolog to the mouse transcription factor HNF‐4 suggests a determinative role in gut formation.
Zhong W, Sladek F, Darnell J. The expression pattern of a Drosophila homolog to the mouse transcription factor HNF‐4 suggests a determinative role in gut formation. The EMBO Journal 1993, 12: 537-544. PMID: 8440243, PMCID: PMC413236, DOI: 10.1002/j.1460-2075.1993.tb05685.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsChromosome DeletionChromosome MappingDNA-Binding ProteinsDrosophilaGene ExpressionHepatocyte Nuclear Factor 4In Situ HybridizationIntestinal MucosaIntestinesKidneyLiverMiceMolecular Sequence DataPhenotypePhosphoproteinsRNA, MessengerSequence Homology, Amino AcidTranscription FactorsConceptsDNA-binding domainDrosophila genesGut formationHNF-4Binding domainIdentical DNA binding domainsZinc finger DNA-binding domainHepatocyte nuclear factor 3Transcription factor HNF-4Amino acidsGroup of genesLiver-specific gene expressionDrosophila homologDrosophila embryoDrosophila mutantsMouse genesHNF-3Cross-hybridizationLate embryogenesisChromosomal deletionsDrosophilaFat bodyGene expressionExpression patternsGenes