Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors
Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs 2013, 6: 108-118. PMID: 24284965, PMCID: PMC3929435, DOI: 10.4161/mabs.27052.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesCell Line, TumorImmunity, CellularImmunoglobulin GLymphomaMiceNeoplasm ProteinsReceptors, FcConceptsT cell responsesFc receptorsTumor cellsT cellsAnti-tumor T cell responsesCell responsesEffective anti-tumor responseAnti-tumor CD8DC vaccine strategiesDendritic cell functionTumor-derived antigensAnti-tumor responseTumor-specific antigensFc regionTherapeutic tumor vaccinesInnate immune responseIgG1 Fc regionSuch tumor cellsSurface of tumorVariety of receptorsProfessional antigenTumor vaccinesVaccine strategiesAntigen uptakePrimary tumor