The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries
van der Veeken J, Glasner A, Zhong Y, Hu W, Wang Z, Bou-Puerto R, Charbonnier L, Chatila T, Leslie C, Rudensky A. The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. Immunity 2020, 53: 971-984.e5. PMID: 33176163, PMCID: PMC8363055, DOI: 10.1016/j.immuni.2020.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityBinding SitesChromatin Assembly and DisassemblyDisease Models, AnimalEpigenesis, GeneticFemaleForkhead Transcription FactorsGene Expression RegulationImmunohistochemistryMaleMiceNucleotide MotifsOrgan SpecificityProtein BindingT-Lymphocytes, RegulatoryTrans-ActivatorsConceptsRegulatory T Cell IdentityChromatin accessibilityCell identityT cell identityDNA sequence motifsGene expression patternsMajor chromatinChromatin regionsTF bindingSequence motifsTCF7 geneEpigenetic featuresGenetic variationNegative regulationNull allelesExpression patternsPresence of DNATreg cell identityFOXP3 functionTCF1MotifIndirect mannerCellsTranscription factor Foxp3Chromatin