Featured Publications
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity
Hu W, Wang Z, Feng Y, Schizas M, Hoyos B, van der Veeken J, Verter J, Bou-Puerto R, Rudensky A. Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity. Nature Immunology 2021, 22: 1163-1174. PMID: 34426690, PMCID: PMC9341271, DOI: 10.1038/s41590-021-01001-4.Peer-Reviewed Original ResearchConceptsRegulatory T cellsTreg cellsFatal autoimmune diseaseSystemic inflammationAutoimmune diseasesT cellsPro-inflammatory effector cellsFatal autoimmune inflammationFOXP3 protein expressionSevere tissue inflammationTranscription factor Foxp3Autoimmune inflammationFatal autoimmunityInflammatory mediatorsEffector cellsImmune activationImmunosuppressive functionTissue inflammationDiseased miceImmune homeostasisInflammatory responseFactor Foxp3Long-term protectionInflammationLoss of functionExpression of Foxp3 by T follicular helper cells in end-stage germinal centers
Jacobsen J, Hu W, R Castro T, Solem S, Galante A, Lin Z, Allon S, Mesin L, Bilate A, Schiepers A, Shalek A, Rudensky A, Victora G. Expression of Foxp3 by T follicular helper cells in end-stage germinal centers. Science 2021, 373 PMID: 34437125, PMCID: PMC9007630, DOI: 10.1126/science.abe5146.Peer-Reviewed Original ResearchConceptsFollicular helper cellsGerminal centersHelper cellsFormation of GCsExpression of Foxp3Effective antibody responseTranscription factor Foxp3Acute surgeAntibody responseFactor Foxp3T cellsFoxp3Immunoglobulin somatic hypermutationGC sizeAffinity maturationPotential regulatorCellsEctopic expressionSomatic hypermutationExpressionAntibodies
2023
Distinct metabolic requirements regulate B cell activation and germinal center responses
Sharma R, Smolkin R, Chowdhury P, Fernandez K, Kim Y, Cols M, Alread W, Yen W, Hu W, Wang Z, Violante S, Chaligné R, Li M, Cross J, Chaudhuri J. Distinct metabolic requirements regulate B cell activation and germinal center responses. Nature Immunology 2023, 1-12. PMID: 37365386, DOI: 10.1038/s41590-023-01540-y.Peer-Reviewed Original ResearchNaïve B cellsB cellsGerminal centersB cell-dependent immune responsesExtrafollicular B cell responsesCell-dependent immune responsesB cell responsesGerminal center responseB cell activationMetabolic requirementsAntibody responseDistinct metabolic requirementsHigh-affinity antibodiesT cellsExtrafollicular sitesImmune responseProliferating lymphocytesCenter responseClonal proliferationCell activationCell responsesGC reactionLactate dehydrogenaseAerobic glycolysisNaïveConserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies
Glasner A, Rose S, Sharma R, Gudjonson H, Chu T, Green J, Rampersaud S, Valdez I, Andretta E, Dhillon B, Schizas M, Dikiy S, Mendoza A, Hu W, Wang Z, Chaudhary O, Xu T, Mazutis L, Rizzuto G, Quintanal-Villalonga A, Manoj P, de Stanchina E, Rudin C, Pe’er D, Rudensky A. Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies. Nature Immunology 2023, 24: 1020-1035. PMID: 37127830, PMCID: PMC10232368, DOI: 10.1038/s41590-023-01504-2.Peer-Reviewed Original ResearchConceptsTreg cell depletionRegulatory T cellsT cellsCell depletionEffector T cellsInjury-induced inflammationTreg cell functionSolid organ cancersAntigen presenting cellsExperimental lung cancerLung adenocarcinoma progressionAccessory cell typesT cell activationRational combination treatmentsTreg cellsCorresponding monotherapiesOrgan cancersLung cancerInjury settingPresenting cellsVEGF blockadeAdenocarcinoma progressionCombination treatmentMyeloid cellsCell activation
2022
Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells
van der Veeken J, Campbell C, Pritykin Y, Schizas M, Verter J, Hu W, Wang Z, Matheis F, Mucida D, Charbonnier L, Chatila T, Rudensky A. Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells. Immunity 2022, 55: 1173-1184.e7. PMID: 35700740, PMCID: PMC9885886, DOI: 10.1016/j.immuni.2022.05.010.Peer-Reviewed Original ResearchConceptsPTreg cellsTranscription factor Foxp3Treg cellsFactor Foxp3Absence of Foxp3Foxp3-independent mannerPeripheral Treg cellsRegulatory T cellsRole of Foxp3Genetic tracingSuppress autoimmunityTolerogenic signalsEffector TT cellsFoxp3Mature CD4Commensal microbiotaCell lineagesCellsCell expansionCell programTTregsColitisCD4Autoimmunity
2013
Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors
Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs 2013, 6: 108-118. PMID: 24284965, PMCID: PMC3929435, DOI: 10.4161/mabs.27052.Peer-Reviewed Original ResearchConceptsT cell responsesFc receptorsTumor cellsT cellsAnti-tumor T cell responsesCell responsesEffective anti-tumor responseAnti-tumor CD8DC vaccine strategiesDendritic cell functionTumor-derived antigensAnti-tumor responseTumor-specific antigensFc regionTherapeutic tumor vaccinesInnate immune responseIgG1 Fc regionSuch tumor cellsSurface of tumorVariety of receptorsProfessional antigenTumor vaccinesVaccine strategiesAntigen uptakePrimary tumor