Distinct metabolic requirements regulate B cell activation and germinal center responses
Sharma R, Smolkin R, Chowdhury P, Fernandez K, Kim Y, Cols M, Alread W, Yen W, Hu W, Wang Z, Violante S, Chaligné R, Li M, Cross J, Chaudhuri J. Distinct metabolic requirements regulate B cell activation and germinal center responses. Nature Immunology 2023, 1-12. PMID: 37365386, DOI: 10.1038/s41590-023-01540-y.Peer-Reviewed Original ResearchNaïve B cellsB cellsGerminal centersB cell-dependent immune responsesExtrafollicular B cell responsesCell-dependent immune responsesB cell responsesGerminal center responseB cell activationMetabolic requirementsAntibody responseDistinct metabolic requirementsHigh-affinity antibodiesT cellsExtrafollicular sitesImmune responseProliferating lymphocytesCenter responseClonal proliferationCell activationCell responsesGC reactionLactate dehydrogenaseAerobic glycolysisNaïve