2023
Distinct metabolic requirements regulate B cell activation and germinal center responses
Sharma R, Smolkin R, Chowdhury P, Fernandez K, Kim Y, Cols M, Alread W, Yen W, Hu W, Wang Z, Violante S, Chaligné R, Li M, Cross J, Chaudhuri J. Distinct metabolic requirements regulate B cell activation and germinal center responses. Nature Immunology 2023, 1-12. PMID: 37365386, DOI: 10.1038/s41590-023-01540-y.Peer-Reviewed Original ResearchNaïve B cellsB cellsGerminal centersB cell-dependent immune responsesExtrafollicular B cell responsesCell-dependent immune responsesB cell responsesGerminal center responseB cell activationMetabolic requirementsAntibody responseDistinct metabolic requirementsHigh-affinity antibodiesT cellsExtrafollicular sitesImmune responseProliferating lymphocytesCenter responseClonal proliferationCell activationCell responsesGC reactionLactate dehydrogenaseAerobic glycolysisNaïve
2013
Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors
Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors. MAbs 2013, 6: 108-118. PMID: 24284965, PMCID: PMC3929435, DOI: 10.4161/mabs.27052.Peer-Reviewed Original ResearchConceptsT cell responsesFc receptorsTumor cellsT cellsAnti-tumor T cell responsesCell responsesEffective anti-tumor responseAnti-tumor CD8DC vaccine strategiesDendritic cell functionTumor-derived antigensAnti-tumor responseTumor-specific antigensFc regionTherapeutic tumor vaccinesInnate immune responseIgG1 Fc regionSuch tumor cellsSurface of tumorVariety of receptorsProfessional antigenTumor vaccinesVaccine strategiesAntigen uptakePrimary tumor