2011
Boosting enrolment in clinical trials: validation of a regional network model
Kernan W, Viscoli C, Brass L, Amatangelo M, Birch A, Clark W, Conwit R, Furie K, Gorman M, Pesapane B, Kleindorfer D, Lovejoy A, Osborne J, Silliman S, Zweifler R, Horwitz R. Boosting enrolment in clinical trials: validation of a regional network model. Clinical Trials 2011, 8: 645-653. PMID: 21824978, PMCID: PMC3852692, DOI: 10.1177/1740774511414925.Peer-Reviewed Original ResearchConceptsClinical trialsTransient ischemic attackNames of patientsEligible patientsIschemic attackStroke preventionDrug adherenceStroke therapyActive surveillanceAverage monthly rateHome visitsPatientsHospitalTrial researchParticipant costsOutreach NetworkMultiple hospitalsTrialsStudy intervalNational InstituteEnrollmentMonthly rateStrokeParticipantsReproducible method
2003
Re: Evaluation of acute candesartan cilexetil therapy in stroke survivors.
Kernan WN. Re: Evaluation of acute candesartan cilexetil therapy in stroke survivors. Stroke 2003, 34: e237-8; author reply e237-8. PMID: 14631078, DOI: 10.1161/01.str.0000104158.59498.bc.Peer-Reviewed Original Research
1999
Stratified Randomization for Clinical Trials
Kernan W, Viscoli C, Makuch R, Brass L, Horwitz R. Stratified Randomization for Clinical Trials. Journal Of Clinical Epidemiology 1999, 52: 19-26. PMID: 9973070, DOI: 10.1016/s0895-4356(98)00138-3.Peer-Reviewed Original ResearchConceptsStratified randomizationSmall trialsInterim analysisActive-control equivalence trialsClinical factorsLarge trialsSuperiority trialSubgroup analysisClinical trialsTreatment responsivenessTreatment outcomesMEDLINE searchTreatment groupsStratification factorsEquivalence trialPrognosisTrialsRandomizationType ITheoretical benefitsImportance of stratificationStratificationSample sizeInvestigatorsPatients
1991
A methodological appraisal of research on prognosis after transient ischemic attacks.
Kernan W, Feinstein A, Brass L. A methodological appraisal of research on prognosis after transient ischemic attacks. Stroke 1991, 22: 1108-1116. PMID: 1926253, DOI: 10.1161/01.str.22.9.1108.Peer-Reviewed Original ResearchConceptsTransient ischemic attackTransient ischemiaIschemic attackEligible studiesAspects of prognosisObservational cohort studyPrognosis of patientsSubgroup of patientsAppropriate end pointsPeer-reviewed journalsCohort studyInception cohortOutcome ratesIndividual patientsDiagnostic criteriaPatientsOutcome riskIschemiaMultivariate analysisPrognosisEnd pointSubsequent strokeAdherencePredictive variablesStroke