2023
Partial Meal Replacement for Weight Loss after Stroke: Results of a Pilot Clinical Trial
Dearborn Tomazos J, Viscoli C, Amin H, Lovelett L, Rivera J, Gull A, Kernan W. Partial Meal Replacement for Weight Loss after Stroke: Results of a Pilot Clinical Trial. Cerebrovascular Diseases 2023, 53: 54-61. PMID: 37231793, DOI: 10.1159/000530996.Peer-Reviewed Original ResearchRecent ischemic strokeBody mass indexIschemic strokeStandard carePMR groupWeight lossSC groupMeal replacementMean percent weight changePartial meal replacementOpen-label trialAcute ischemic strokeCo-primary outcomesHalf of patientsSuccessful weight lossPilot clinical trialPercent weight changeBMI 27Eligible patientsAdverse eventsObese patientsMass indexVascular inflammationLarge trialsFunctional outcome
2016
Pioglitazone after Ischemic Stroke or Transient Ischemic Attack
Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR. Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. New England Journal Of Medicine 2016, 374: 1321-1331. PMID: 26886418, PMCID: PMC4887756, DOI: 10.1056/nejmoa1506930.Peer-Reviewed Original ResearchConceptsTransient ischemic attackIschemic strokeInsulin resistanceMyocardial infarctionIschemic attackPrimary outcomeRecent ischemic strokeDouble-blind trialFuture cardiovascular eventsHomeostasis model assessmentInsulin resistance indexRisk of strokeEligible patientsNonfatal strokePioglitazone groupCardiovascular eventsCause mortalityPlacebo groupPreventive therapyCerebrovascular diseaseInsulin sensitivityRisk factorsResistance indexHigh riskLower risk
2011
Boosting enrolment in clinical trials: validation of a regional network model
Kernan W, Viscoli C, Brass L, Amatangelo M, Birch A, Clark W, Conwit R, Furie K, Gorman M, Pesapane B, Kleindorfer D, Lovejoy A, Osborne J, Silliman S, Zweifler R, Horwitz R. Boosting enrolment in clinical trials: validation of a regional network model. Clinical Trials 2011, 8: 645-653. PMID: 21824978, PMCID: PMC3852692, DOI: 10.1177/1740774511414925.Peer-Reviewed Original ResearchConceptsClinical trialsTransient ischemic attackNames of patientsEligible patientsIschemic attackStroke preventionDrug adherenceStroke therapyActive surveillanceAverage monthly rateHome visitsPatientsHospitalTrial researchParticipant costsOutreach NetworkMultiple hospitalsTrialsStudy intervalNational InstituteEnrollmentMonthly rateStrokeParticipantsReproducible method
2005
Prevalence of Abnormal Glucose Tolerance Following a Transient Ischemic Attack or Ischemic Stroke
Kernan WN, Viscoli CM, Inzucchi SE, Brass LM, Bravata DM, Shulman GI, McVeety JC. Prevalence of Abnormal Glucose Tolerance Following a Transient Ischemic Attack or Ischemic Stroke. JAMA Internal Medicine 2005, 165: 227-233. PMID: 15668371, DOI: 10.1001/archinte.165.2.227.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overBlood GlucoseCohort StudiesFemaleGlucose IntoleranceGlucose Tolerance TestHumansIschemic Attack, TransientLogistic ModelsMaleMiddle AgedOdds RatioPrevalenceProbabilityPrognosisProspective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionStrokeConceptsTransient ischemic attackDiabetic glucose toleranceImpaired glucose toleranceAbnormal glucose tolerancePlasma glucose levelsRecent transient ischemic attackGlucose toleranceIschemic strokeGlucose levelsIschemic attackPhysician-diagnosed diabetes mellitusOral glucose tolerance testStepwise logistic regression modelIncident vascular diseaseRecurrent brain diseaseVascular disease mortalityHistory of diabetesClinical Research CenterGlucose tolerance testLower waist circumferencePlasma glucose valuesForward stepwise logistic regression modelLogistic regression modelsEligible patientsAntihyperglycemic therapy
2003
Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke
Kernan WN, Inzucchi SE, Viscoli CM, Brass LM, Bravata DM, Shulman GI, McVeety JC, Horwitz RI. Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke. Neurology 2003, 60: 1447-1451. PMID: 12743229, DOI: 10.1212/01.wnl.0000063318.66140.a3.Peer-Reviewed Original ResearchConceptsImpaired insulin sensitivityIschemic strokeInsulin sensitivityRecent TIANondiabetic patientsMyocardial infarctionComposite insulin sensitivity indexInsulin sensitivity index valuesOral glucose tolerance testAge 45 yearsGlucose tolerance testInsulin sensitivity indexImportant therapeutic implicationsEligible patientsNondiabetic menStroke etiologyEligible subjectsMedian ageYounger patientsTolerance testHeart diseaseTherapeutic implicationsPatientsGlucose valuesStroke
1994
Gender difference in prognosis after transient cerebral ischemia or minor stroke
Kernan W, Horwitz R, Brass L, Viscoli C. Gender difference in prognosis after transient cerebral ischemia or minor stroke. Journal Of Stroke And Cerebrovascular Diseases 1994, 4: 148-154. PMID: 26486051, DOI: 10.1016/s1052-3057(10)80177-6.Peer-Reviewed Original ResearchTransient ischemic attackTransient cerebral ischemiaCrude relative riskMinor strokeRelative riskIschemic attackCerebral ischemiaCarotid transient ischemic attacksInitial transient ischemic attackRisk of strokeGender differencesEligible patientsComorbid illnessesPrognostic strataStrokeLarger studyStudy outcomesWomenStatistical significanceMenIschemiaPrognosisRiskEffect of genderDeath
1991
A prognostic system for transient ischemia or minor stroke.
Kernan WN, Horwitz RI, Brass LM, Viscoli CM, Taylor KJ. A prognostic system for transient ischemia or minor stroke. Annals Of Internal Medicine 1991, 114: 552-7. PMID: 2001088, DOI: 10.7326/0003-4819-114-7-552.Peer-Reviewed Original ResearchConceptsCarotid transient ischemic attacksTransient ischemic attackMinor strokeOutcome ratesRisk group 1Ischemic attackTransient ischemiaPrognostic systemGroup 1Urban community teaching hospitalInception cohort studyCommunity teaching hospitalEligible patientsCohort studyClinical featuresOriginal cohortTeaching hospitalTest cohortStrokePatientsSubsequent strokeHypertensionIschemiaDeathDiabetes