2001
Involvement of CD1 in Peripheral Deletion of T Lymphocytes Is Independent of NK T Cells
Dao T, Exley M, Mehal W, Tahir S, Snapper S, Taniguchi M, Balk S, Crispe I. Involvement of CD1 in Peripheral Deletion of T Lymphocytes Is Independent of NK T Cells. The Journal Of Immunology 2001, 166: 3090-3097. PMID: 11207260, DOI: 10.4049/jimmunol.166.5.3090.Peer-Reviewed Original ResearchConceptsNK T cellsPeripheral T cell deletionT cell deletionT cellsCell deletionCD1-deficient miceBone marrow chimerasExpression of CD1T cell activationMHC-like moleculesNonlymphoid organsLymph nodesPeripheral deletionNormal miceT lymphocytesCell activationMutant mouse linesMouse linesAttenuated accumulationMiceLymphocytesNovel roleCD1Ab resultsLiver
1999
Selective retention of activated CD8+ T cells by the normal liver.
Mehal W, Juedes A, Crispe I. Selective retention of activated CD8+ T cells by the normal liver. The Journal Of Immunology 1999, 163: 3202-10. PMID: 10477588, DOI: 10.4049/jimmunol.163.6.3202.Peer-Reviewed Original Research
1998
IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells.
Dao T, Mehal W, Crispe I. IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells. The Journal Of Immunology 1998, 161: 2217-22. PMID: 9725214, DOI: 10.4049/jimmunol.161.5.2217.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsCytokinesCytotoxicity, ImmunologicHumansInterferon InducersInterferon-gammaInterleukin-18Jurkat CellsKiller Cells, NaturalLiverLymphoproliferative DisordersMembrane GlycoproteinsMiceMice, Inbred C57BLMice, Inbred StrainsMice, KnockoutPerforinPore Forming Cytotoxic ProteinsT-Lymphocyte SubsetsT-Lymphocytes, CytotoxicTumor Necrosis Factor-alphaConceptsNK T cellsLiver NK T cellsIL-18NK cellsIntrahepatic lymphocyte subpopulationsNK cell activityPerforin-dependent cytotoxicityPerforin-dependent pathwayTNF-alpha productionSoluble TNF-alphaT cell linesLymphocyte subpopulationsCytotoxic cellsTNF-alphaT cellsCell activityExact mechanismNKCell populationsCell linesLiverCytotoxicityCellsCytokinesCTLTCR ligation on CD8+ T cells creates double-negative cells in vivo.
Mehal W, Crispe I. TCR ligation on CD8+ T cells creates double-negative cells in vivo. The Journal Of Immunology 1998, 161: 1686-93. PMID: 9712032, DOI: 10.4049/jimmunol.161.4.1686.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Polyomavirus TransformingCD8-Positive T-LymphocytesClonal DeletionFas ReceptorHistocompatibility Antigens Class IImmunophenotypingInjections, IntraperitonealLiverLymph NodesLymphocyte CountLymphocyte DepletionMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte Subsets